Sulfuric Acid — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 CALCRL CHRM1 CHRM2 CHRM3 F2R MAOA MAOB MAP2K1 MAP2K2 NTRK1 NTRK2 NTRK3 OPRD1 OPRK1 OPRM1 P2RY12 PKLR SCN10A SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A SLC18A2 SLC6A2 SLC6A3 TLR7 TLR9 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 dacA dacB dacC folA ftsI mrcA mrcB mrdA pol rplA rplB rplC rplD rplE rplF rplI rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmB1 rpmB2 rpmC rpmD rpmE rpmE2 rpmF rpmG rpmG1 rpmG2 rpmH rpmI rpmJ rpmJ2 rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsR1 rpsR2 rpsS rpsT rpsU rpsZ ykgM ykgO

The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 18)

	gene	UniProt	supporting neighbours	confidence
▸	NAAA	Q02083	1/20	0.46

▸	SPHK1	Q9NYA1	1/20	0.45

▸	EPHX1	P07099	1/20	0.43

▸	TSHR	P16473	4/20	0.42

▸	RECQL	P46063	2/20	0.41

▸	GLA	P06280	1/20	0.41

▸	HPGD	P15428	1/20	0.41

▸	MAPK1	P28482	1/20	0.41

▸	EPHX2	P34913	1/20	0.41

▸	TP53	P04637	1/20	0.41

▸	BLM	P54132	1/20	0.41

▸	HCAR2	Q8TDS4	1/20	0.40

▸	RAD52	P43351	1/20	0.40

▸	NPSR1	Q6W5P4	1/20	0.40

▸	FAAH	O00519	1/20	0.39

▸	DNM1	Q05193	1/20	0.39

▸	ALDH1A1	P00352	1/20	0.39

▸	LMNA	P02545	1/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL15568890	0.95	EPHX1 (0.46)	NAAASPHK1EPHX1TSHRRECQL
SCHEMBL15568921	0.95	NAAA (0.44)	NAAASPHK1EPHX1TSHRRECQL
SCHEMBL15305328	0.93	NAAA (0.52)	NAAASPHK1EPHX1TSHRHCAR2
SCHEMBL15305326	0.93	NAAA (0.52)	NAAASPHK1EPHX1TSHRHCAR2
SCHEMBL27733410	0.93	NAAA (0.52)	NAAASPHK1EPHX1TSHRHCAR2
SCHEMBL15796319	0.93	NAAA (0.52)	NAAASPHK1EPHX1TSHRHCAR2
SCHEMBL138880	0.93	NAAA (0.52)	NAAASPHK1EPHX1TSHRHCAR2
SCHEMBL453610	0.93	NAAA (0.52)	NAAASPHK1EPHX1TSHRHCAR2
SCHEMBL15796587	0.93	NAAA (0.52)	NAAASPHK1EPHX1TSHRHCAR2
SCHEMBL21184186	0.93	NAAA (0.52)	NAAASPHK1EPHX1TSHRHCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20140170207-A1	ANTIMICROBIAL COMPOUNDS AND METHODS OF USE	NEXMED HOLDINGS, INC.	2014-06-19	—	—	US	claimed
EP-1278495-A4	TOPICAL COMPOSITIONS CONTAINING PROSTAGLANDIN E 1?	NEXMED HOLDINGS INC (US)	2006-03-22	—	—	EP	claimed
EP-1097126-B1	CRYSTALLINE SALTS OF DODECYL 2-(N,N-DIMETHYLAMINO)-PROPIONATE	NEXMED HOLDINGS INC (US)	2004-08-04	—	—	EP	claimed
EP-1278495-A1	TOPICAL COMPOSITIONS CONTAINING PROSTAGLANDIN E 1?	Nexmed Holdings, Inc. (US)	2003-01-29	—	—	EP	claimed
EP-1097126-A4	CRYSTALLINE SALTS OF DODECYL 2-(N,N-DIMETHYLAMINO)-PROPIONATE	NEXMED HOLDINGS INC (US)	2002-08-28	—	—	EP	claimed
US-6414028-B1	MIXTURE WITH SKIN PENETRATION INTENSIFIER, POLYSACCHARIDE GUM AND BUFFER	NEXMED HOLDINGS, INC.	2002-07-02	—	—	US	claimed
WO-2001074279-A1	TOPICAL COMPOSITIONS CONTAINING PROSTAGLANDIN E¿1?	NEXMED HOLDINGS, INC. (US)	2001-10-11	—	—	WO	claimed
EP-1097126-A1	CRYSTALLINE SALTS OF DODECYL 2-(N,N-DIMETHYLAMINO)-PROPIONATE	Nexmed Holdings, Inc. (US)	2001-05-09	—	—	EP	claimed
WO-2000069809-A1	CRYSTALLINE SALTS OF DODECYL 2-(N,N-DIMETHYLAMINO)-PROPIONATE	NEXMED HOLDINGS, INC. (US)	2000-11-23	—	—	WO	claimed
US-6118020-A	SALT FORMATION, PRECIPITATION, TRANSDERMAL DRUG DELIVERY PENETRATION AGENT	NEXMED HOLDINGS, INC. (US)	2000-09-12	—	—	US	claimed
US-20150079163-A1	ANTIMICROBIAL COMPOUNDS AND METHODS OF USE	NEXMED HOLDINGS, INC.	2015-03-19	—	—	US	disclosed
US-20140357713-A1	ANTIMICROBIAL COMPOUNDS AND METHODS OF USE	NEXMED HOLDINGS, INC. (US)	2014-12-04	—	—	US	disclosed
US-8900625-B2	Antimicrobial compounds and methods of use	NEXMED HOLDINGS, INC. (US)	2014-12-02	—	—	US	disclosed
US-20140170207-A1	ANTIMICROBIAL COMPOUNDS AND METHODS OF USE	NEXMED HOLDINGS, INC.	2014-06-19	—	—	US	disclosed
WO-2014028780-A2	ANTIFUNGAL COMPOUNDS AND METHODS OF USE	NEXMED HOLDINGS, INC. (US)	2014-02-20	—	—	WO	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20150079163-A1	ANTIMICROBIAL COMPOUNDS AND METHODS OF USE	CLPP, POLR1C, NACA	NAAA 189/4885SPHK1 2815/4885EPHX1 3515/4885
US-20140170207-A1	ANTIMICROBIAL COMPOUNDS AND METHODS OF USE	CLPP, POLR1C, NACA	NAAA 189/4885SPHK1 2815/4885EPHX1 3515/4885
US-20140357713-A1	ANTIMICROBIAL COMPOUNDS AND METHODS OF USE	CLPP, POLR1C, NACA	NAAA 189/4885SPHK1 2815/4885EPHX1 3515/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.