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Sugi Predict / Compounds / Hydroxyprogesterone

Hydroxyprogesterone

Hydroxyprogesterone

SCHEMBL5664516

CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C.CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(O)C[C@]12C.C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)CO

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 10/20 0.71
▸ LMNA P02545 8/20 0.71
▸ HIF1A Q16665 8/20 0.71
▸ CYP3A4 P08684 7/20 0.71
▸ SHBG P04278 7/20 0.71
▸ SERPINA6 P08185 7/20 0.71
▸ MAPT P10636 6/20 0.71
▸ NR3C2 P08235 5/20 0.71
▸ HSD17B10 Q99714 5/20 0.71
▸ MAPK1 P28482 4/20 0.71
▸ CYP2C9 P11712 3/20 0.71
▸ TSHR P16473 3/20 0.71
▸ BLM P54132 3/20 0.71
▸ SLC22A2 O15244 2/20 0.71
▸ SLC22A1 O15245 2/20 0.71
▸ SLC22A3 O75751 2/20 0.71
▸ THPO P40225 2/20 0.71
▸ SIGMAR1 Q99720 2/20 0.71
▸ NFKB1 P19838 2/20 0.71
▸ MTOR P42345 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydroxyprogesterone SCHEMBL6037033 0.90 LMNA (0.80) SMN1; SMN2LMNAHIF1ACYP3A4SHBG
Hydrocortisone SCHEMBL5665147 0.90 HIF1A (0.68) SMN1; SMN2LMNAHIF1ACYP3A4SHBG
Cortodoxone SCHEMBL28857468 0.90 SMN1; SMN2 (0.71) SMN1; SMN2LMNAHIF1ACYP3A4SHBG
Corticosterone SCHEMBL5662984 0.90 LMNA (0.78) SMN1; SMN2LMNAHIF1ACYP3A4SHBG
Corticosterone SCHEMBL5323007 0.89 SMN1; SMN2 (0.89) SMN1; SMN2LMNAHIF1ACYP3A4SHBG
Hydrocortisone SCHEMBL6715475 0.87 HIF1A (0.78) SMN1; SMN2LMNAHIF1ACYP3A4SHBG
Hydrocortisone SCHEMBL8570579 0.87 HIF1A (0.78) SMN1; SMN2LMNAHIF1ACYP3A4SHBG
Hydroxyprogesterone SCHEMBL8814591 0.87 SMN1; SMN2 (0.81) SMN1; SMN2LMNAHIF1ACYP3A4SHBG
Corticosterone SCHEMBL9264007 0.85 LMNA (0.84) SMN1; SMN2LMNAHIF1ACYP3A4SHBG
Hydrocortisone SCHEMBL5328946 0.85 HIF1A (0.82) SMN1; SMN2LMNAHIF1ACYP3A4SHBG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1404717-A4 KINETIC ASSAY HORTICULTURE & FOOD RES INST (NZ) 2006-03-08 — — EP claimed
EP-1404717-A1 KINETIC ASSAY The Horticulture and Food Research Institute of New Zealand Limited (NZ) 2004-04-07 — — EP claimed
WO-2002092631-A1 KINETIC ASSAY THE HORTICULTURE AND FOOD RESEARCH INSTITUTE OF NEW ZEALAND LIMITED (NZ) 2002-11-21 — — WO claimed