Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glutamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamine SCHEMBL3047068 | 1.00 | ALOX15 (0.36) | ALOX15BLMPMP22KMT2APTGS1 | |
| Glutamine SCHEMBL6860254 | 0.99 | ALOX15 (0.36) | ALOX15BLMPMP22KMT2APTGS1 | |
| Glutamine SCHEMBL5665046 | 0.96 | ALOX15 (0.40) | ALOX15BLMPMP22KMT2APTGS1 | |
| Glutamine SCHEMBL6377469 | 0.96 | ALOX15 (0.40) | ALOX15BLMPMP22KMT2APTGS1 | |
| Glutamine SCHEMBL6369944 | 0.95 | ALOX15 (0.39) | ALOX15BLMPMP22KMT2APTGS1 | |
| Glutamine SCHEMBL5663861 | 0.95 | ALOX15 (0.40) | ALOX15BLMPMP22KMT2A | |
| Glutamine SCHEMBL6860246 | 0.95 | ALOX15 (0.33) | ALOX15BLMPMP22KMT2A | |
| Glutamine SCHEMBL5665397 | 0.94 | ALOX15 (0.41) | ALOX15BLMPMP22KMT2APTGS1 | |
| Glutamine SCHEMBL6517171 | 0.94 | ALOX15 (0.41) | ALOX15BLMPMP22KMT2APTGS1 | |
| Glutamine SCHEMBL6371388 | 0.93 | ALOX15 (0.40) | ALOX15BLMPMP22KMT2APTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392346-A4 | COMPOSITION AND METHOD FOR ENHANCING ELASTICITY OF TISSUE | CONNECTIVE TISSUE IMAGINEERING (US) | 2006-10-25 | — | — | EP | disclosed |
| EP-1392346-A2 | COMPOSITION AND METHOD FOR ENHANCING ELASTICITY OF TISSUE | Connective Tissue Imagineering LLC (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2001091700-A2 | COMPOSITION AND METHOD FOR ENHANCING ELASTICITY OF TISSUE | CONNECTIVE TISSUE IMAGINEERING LLC (US) | 2001-12-06 | — | — | WO | disclosed |