Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 4/20 | 0.53 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.38 |
| ▸ | PRKCG | P05129 | 6/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 6/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 5/20 | 0.38 |
| ▸ | PRKCB | P05771 | 5/20 | 0.38 |
| ▸ | PRKCA | P17252 | 5/20 | 0.38 |
| ▸ | PRKCH | P24723 | 5/20 | 0.38 |
| ▸ | PRKCI | P41743 | 5/20 | 0.38 |
| ▸ | PRKCE | Q02156 | 5/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.38 |
| ▸ | PRKD1 | Q15139 | 5/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.38 |
| ▸ | PRKACA | P17612 | 5/20 | 0.38 |
| ▸ | PRKACG | P22612 | 4/20 | 0.38 |
| ▸ | PRKACB | P22694 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL568126 | 0.78 | HASPIN (0.49) | IMPDH2ERN1CYP3A4PRKCGPRKCZ | |
| SCHEMBL115053 | 0.76 | CYP3A4 (0.56) | CYP3A4PRKCGPRKCZPRKCDPRKD3 | |
| SCHEMBL29546384 | 0.76 | CYP3A4 (0.56) | CYP3A4PRKCGPRKCZPRKCDPRKD3 | |
| SCHEMBL5009195 | 0.75 | PRKACA (0.37) | IMPDH2ERN1CYP3A4PRKCGPRKCZ | |
| SCHEMBL7115130 | 0.75 | POLB (0.47) | ERN1HIF1ACYP1A2SMN1; SMN2TSHR | |
| SCHEMBL17709907 | 0.75 | AXL (0.51) | IMPDH2CYP3A4MEN1KMT2ATP53 | |
| Hydrochloric Acid SCHEMBL29469852 | 0.75 | LMNA (0.57) | CYP3A4PRKCGPRKCZPRKCDPRKD3 | |
| Hydrochloric Acid SCHEMBL987360 | 0.75 | LMNA (0.57) | CYP3A4PRKCGPRKCZPRKCDPRKD3 | |
| SCHEMBL3010471 | 0.71 | CA12 (0.40) | CYP3A4MEN1KMT2ATP53LMNA | |
| SCHEMBL21903918 | 0.70 | PRKD3 (0.38) | IMPDH2ERN1CYP3A4PRKCGPRKCZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2657227-B1 | NOVEL SUBSTITUTED ISOQUINOLINE DERIVATIVE | WESTERN THERAPEUTICS INST INC D (JP) | 2016-04-27 | — | — | EP | disclosed |
| CN-102448941-B | The isoquinilone derivatives replaced | D. WESTERN THERAPEUTICS INSTITUTE, INC. (JP) | 2016-04-06 | — | — | CN | disclosed |
| EP-2444395-B1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | WESTERN THERAPEUTICS INST INC D (JP) | 2016-01-06 | — | — | EP | disclosed |
| EP-2444395-B1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | WESTERN THERAPEUTICS INST INC D (JP) | 2016-01-06 | — | — | EP | disclosed |
| CN-103270024-B | Novel substituted isoquinoline derivative | WESTERN THERAPEUTICS INST INC | 2015-07-08 | — | — | CN | disclosed |
| US-8951997-B2 | Substituted isoquinoline derivative | D. WESTERN THERAPEUTICS INSTITUTE, INC. (JP) | 2015-02-10 | — | — | US | disclosed |
| US-8951997-B2 | Substituted isoquinoline derivative | D. WESTERN THERAPEUTICS INSTITUTE, INC. (JP) | 2015-02-10 | — | — | US | disclosed |
| US-8883792-B2 | Substituted isoquinoline derivative | D. WESTERN THERAPEUTICS INSTITUTE, INC. (JP) | 2014-11-11 | — | — | US | disclosed |
| EP-2657227-A1 | NOVEL SUBSTITUTED ISOQUINOLINE DERIVATIVE | D. Western Therapeutics Institute, Inc. (JP) | 2013-10-30 | — | — | EP | disclosed |
| US-20130274269-A1 | NOVEL SUBSTITUTED ISOQUINOLINE DERIVATIVE | D. WESTERN THERAPEUTICS INSTITUTE, INC. (JP) | 2013-10-17 | — | — | US | disclosed |
| CN-103270024-A | Novel substituted isoquinoline derivative | WESTERN THERAPEUTICS INST INC | 2013-08-28 | — | — | CN | disclosed |
| EP-2444395-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | D. Western Therapeutics Institute, Inc. (JP) | 2012-04-25 | — | — | EP | disclosed |
| US-20120035159-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | D. WESTERN THERAPEUTICS INSTITUTE, INC (JP) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274269-A1 | NOVEL SUBSTITUTED ISOQUINOLINE DERIVATIVE | SULT2A1, SULT1A1, SFPQ | IMPDH2 324/4885ERN1 2952/4885CYP3A4 447/4885 |
| US-20120035159-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | SULT1A1, SULT1E1, SULT2A1 | IMPDH2 702/4885ERN1 2319/4885CYP3A4 662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.