Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 3/20 | 0.38 |
| ▸ | NOS1 | P29475 | 7/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | TEC | P42680 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5664866 | 0.89 | KLKB1 (0.40) | HDAC3LMNAPOLBTSHRRAB9A | |
| SCHEMBL4985659 | 0.87 | MEN1 (0.42) | PLAUNOS1 | |
| SCHEMBL5664693 | 0.87 | PLAU (0.40) | PLAUNOS1POLB | |
| SCHEMBL5669411 | 0.82 | TLR2 (0.39) | PLAU | |
| SCHEMBL5664692 | 0.76 | KLKB1 (0.38) | POLBRAB9A | |
| SCHEMBL4985651 | 0.75 | MEN1 (0.41) | — | |
| SCHEMBL5664400 | 0.75 | MTTP (0.46) | — | |
| SCHEMBL5664394 | 0.75 | MTTP (0.46) | — | |
| SCHEMBL5664748 | 0.72 | BCHE (0.34) | PLAUNOS1LMNAPOLBRAB9A | |
| SCHEMBL5669409 | 0.72 | KLKB1 (0.39) | PLAUPOLBHSD17B10HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716137-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | Pfizer Products Incorporated (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080373-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2005-09-01 | — | — | WO | disclosed |