Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 3/20 | 0.40 |
| ▸ | NOS1 | P29475 | 6/20 | 0.39 |
| ▸ | MTTP | P55157 | 6/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5664692 | 0.89 | KLKB1 (0.38) | MTTPPDK1POLB | |
| SCHEMBL5664871 | 0.87 | PLAU (0.38) | PLAUNOS1POLB | |
| SCHEMBL5669411 | 0.78 | TLR2 (0.39) | PLAU | |
| SCHEMBL5664866 | 0.76 | KLKB1 (0.40) | POLB | |
| SCHEMBL4985659 | 0.76 | MEN1 (0.42) | PLAUNOS1MTTP | |
| SCHEMBL5666298 | 0.74 | PLAU (0.36) | PLAUNOS1NOS2 | |
| SCHEMBL5664748 | 0.73 | BCHE (0.34) | PLAUNOS1NOS2POLB | |
| SCHEMBL3265641 | 0.70 | MTTP (0.70) | MTTP | |
| SCHEMBL3228150 | 0.70 | MTTP (0.70) | MTTP | |
| SCHEMBL5664717 | 0.70 | HPGD (0.51) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716137-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | Pfizer Products Incorporated (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080373-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2005-09-01 | — | — | WO | disclosed |