Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 3/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MTTP | P55157 | 7/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5664693 | 0.89 | PLAU (0.40) | MTTPPDK1POLB | |
| SCHEMBL5664866 | 0.87 | KLKB1 (0.40) | KLKB1MAP4K1RAB9AMEN1KMT2A | |
| SCHEMBL5669409 | 0.78 | KLKB1 (0.39) | KLKB1MAP4K1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL4985651 | 0.77 | MEN1 (0.41) | KLKB1MAP4K1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL5664871 | 0.76 | PLAU (0.38) | RAB9APOLB | |
| SCHEMBL5666297 | 0.75 | KLKB1 (0.37) | KLKB1MAP4K1KDM4ENPC1RAB9A | |
| SCHEMBL5664741 | 0.74 | RAB9A (0.36) | KLKB1MAP4K1KDM4ENPC1RAB9A | |
| SCHEMBL5667134 | 0.71 | OPRM1 (0.40) | KLKB1MAP4K1KDM4ESMN1; SMN2OPRM1 | |
| SCHEMBL5664717 | 0.68 | HPGD (0.51) | KDM4ESMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL4986144 | 0.67 | MEN1 (0.40) | KDM4ESMN1; SMN2NPC1RAB9AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716137-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | Pfizer Products Incorporated (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080373-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2005-09-01 | — | — | WO | disclosed |