Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 3/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.39 |
| ▸ | TLR2 | O60603 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | MC3R | P41968 | 1/20 | 0.38 |
| ▸ | MC1R | Q01726 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5669411 | 0.90 | TLR2 (0.39) | TLR2MC4RMC3RMC1RALOX12 | |
| SCHEMBL5667134 | 0.84 | OPRM1 (0.40) | KLKB1MAP4K1ALOX12PLGPRSS1 | |
| SCHEMBL5664866 | 0.83 | KLKB1 (0.40) | KLKB1MAP4K1MEN1KMT2ANOD2 | |
| SCHEMBL5664692 | 0.78 | KLKB1 (0.38) | KLKB1MAP4K1MEN1KMT2AKDM4E | |
| SCHEMBL5664782 | 0.75 | MTTP (0.43) | — | |
| SCHEMBL5667138 | 0.74 | ALOX12 (0.36) | ALOX12PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL4985651 | 0.72 | MEN1 (0.41) | KLKB1MAP4K1PRSS1PRSS2PRSS3 | |
| SCHEMBL5664741 | 0.72 | RAB9A (0.36) | KLKB1MAP4K1KDM4EALDH1A1POLB | |
| SCHEMBL5664871 | 0.72 | PLAU (0.38) | PLAUHSD17B10HTR2APOLB | |
| SCHEMBL5666297 | 0.69 | KLKB1 (0.37) | KLKB1MAP4K1MC4RMC3RMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716137-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | Pfizer Products Incorporated (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080373-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2005-09-01 | — | — | WO | disclosed |