Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | MC3R | P41968 | 1/20 | 0.37 |
| ▸ | MC1R | Q01726 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 3/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | NAAA | Q02083 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.35 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 2/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5669409 | 0.90 | KLKB1 (0.39) | TLR2MC4RMC3RMC1RALOX12 | |
| SCHEMBL5667138 | 0.82 | ALOX12 (0.36) | ALOX12PLAUNAAAALOX15ASAH1 | |
| SCHEMBL5664871 | 0.82 | PLAU (0.38) | PLAU | |
| SCHEMBL5664782 | 0.77 | MTTP (0.43) | — | |
| SCHEMBL5667134 | 0.73 | OPRM1 (0.40) | ALOX12PLAUNAAAALOX15PLG | |
| SCHEMBL5669914 | 0.72 | KDM4E (0.48) | PLAUNAAAPRSS1 | |
| SCHEMBL13993519 | 0.72 | KDM4E (0.48) | PLAUNAAAPRSS1 | |
| SCHEMBL5664866 | 0.72 | KLKB1 (0.40) | — | |
| SCHEMBL4985659 | 0.71 | MEN1 (0.42) | PLAUSMN1; SMN2 | |
| SCHEMBL5664193 | 0.70 | ALOX12 (0.52) | TLR2ALOX12NAAAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716137-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | Pfizer Products Incorporated (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080373-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2005-09-01 | — | — | WO | disclosed |