Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | S100A4 | P26447 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 5/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL566736 | 1.00 | ACHE (0.53) | ACHECES1MAOAAKR1B1ALDH1A1 | |
| SCHEMBL565749 | 0.82 | ACHE (0.53) | ACHECES1MAOAAKR1B1ALDH1A1 | |
| SCHEMBL567340 | 0.82 | ACHE (0.53) | ACHECES1MAOAAKR1B1ALDH1A1 | |
| SCHEMBL565750 | 0.82 | ACHE (0.53) | ACHECES1MAOAAKR1B1ALDH1A1 | |
| SCHEMBL31123671 | 0.72 | ACHE (0.59) | ACHECES1MAOAAKR1B1ALDH1A1 | |
| SCHEMBL86279 | 0.72 | ACHE (0.59) | ACHECES1MAOAAKR1B1ALDH1A1 | |
| SCHEMBL31510701 | 0.72 | ACHE (0.59) | ACHECES1MAOAAKR1B1ALDH1A1 | |
| SCHEMBL5845169 | 0.70 | ACHE (1.00) | ACHECES1MAOAAKR1B1ALDH1A1 | |
| SCHEMBL16138800 | 0.69 | ACHE (0.50) | ACHECES1MAOAAKR1B1ALDH1A1 | |
| SCHEMBL7195690 | 0.68 | MIF (0.62) | CES1MAOAALDH1A1BCHECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140296285-A1 | PREPARATION AND APPLICATION OF THE NEW ANTIBACTERIAL AND ANTICANCER COMPOUNDS AND THEIR DERIVATIVES | YANG GENGLIANG (CN) | 2014-10-02 | — | — | US | disclosed |
| EP-2423213-B1 | PREPARATION AND USE OF NOVEL ANTIBIOTIC, ANTICANCER COMPOUNDS AND DERIVATIVES THEREOF | YANG GENGLIANG (CN) | 2014-01-08 | — | — | EP | disclosed |
| EP-2423213-A1 | PREPARATION AND USE OF NOVEL ANTIBIOTIC, ANTICANCER COMPOUNDS AND DERIVATIVES THEREOF | Yang, Gengliang (CN) | 2012-02-29 | — | — | EP | disclosed |
| US-20120035206-A1 | PREPARATION AND APPLICATION OF NOVEL ANTIBACTERIAL AND ANTICANCER COMPOUNDS AND THEIR DERIVATIVES | YANG, Gengliang (CN) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035206-A1 | PREPARATION AND APPLICATION OF NOVEL ANTIBACTERIAL AND ANTICANCER COMPOUNDS AND THEIR DERIVATIVES | MRPL21, NRDC, SOST | ACHE 2202/4885CES1 3820/4885MAOA 4297/4885 |
| US-20140296285-A1 | PREPARATION AND APPLICATION OF THE NEW ANTIBACTERIAL AND ANTICANCER COMPOUNDS AND THEIR DERIVATIVES | MRPL21, MCL1, MYC | ACHE 1217/4885CES1 3694/4885MAOA 798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.