Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | CES1 | P23141 | 2/20 | 0.48 |
| ▸ | MIF | P14174 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31123671 | 1.00 | ACHE (0.59) | ACHEAKR1B1MAOAMAPK14CES1 | |
| SCHEMBL31510701 | 1.00 | ACHE (0.59) | ACHEAKR1B1MAOAMAPK14CES1 | |
| SCHEMBL216973 | 0.83 | ACHE (0.56) | ACHEAKR1B1ALDH1A1CHRM2ADRA2A | |
| SCHEMBL4231216 | 0.81 | MAPK14 (0.62) | ACHEAKR1B1MAOAMAPK14CES1 | |
| SCHEMBL86333 | 0.81 | AKR1B1 (0.46) | ACHEAKR1B1MAOAMAPK14MIF | |
| SCHEMBL86390 | 0.81 | AKR1B1 (0.49) | ACHEAKR1B1MAOAMAPK14CES1 | |
| SCHEMBL7243476 | 0.81 | ALDH1A1 (0.54) | ACHEAKR1B1MAOAMAPK14MIF | |
| SCHEMBL11873711 | 0.81 | ELANE (0.51) | ACHEAKR1B1MAOAMAPK14MIF | |
| SCHEMBL85994 | 0.81 | AKR1B1 (0.49) | ACHEAKR1B1MAOAMAPK14CES1 | |
| SCHEMBL86282 | 0.81 | AKR1B1 (0.46) | ACHEAKR1B1MAPK14MIFMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-7109273-A | — | — | None | — | — | JP | disclosed |
| EP-4692092-A1 | NOVEL COMPOUNDS WITH MTORC2-INHIBITORY ACTIVITY AND USES THEREOF | Aliad Biopharma (KR) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024205377-A1 | NOVEL COMPOUNDS WITH MTORC2-INHIBITORY ACTIVITY AND USES THEREOF | 알리아드바이오파마 주식회사 | 2024-10-03 | — | — | WO | disclosed |
| WO-2023122260-A2 | INHIBITORS OF SARS-COV-2 | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2023-06-29 | — | — | WO | disclosed |
| US-20210186969-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | Janssen Biopharma, Inc. (US) | 2021-06-24 | — | — | US | disclosed |
| US-20200339565-A1 | PRODRUG SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2020-10-29 | — | — | US | disclosed |
| EP-3030566-B1 | 7,8-DIHYDRO-3H-PYRAZINO[1,2-B]PYRIDAZINE-3,5(6H)-DIONE COMPOUNDS AND USES THEREOF | JANSSEN BIOPHARMA INC (US) | 2020-07-08 | — | — | EP | disclosed |
| US-10702523-B2 | AZA-pyridone compounds and uses thereof | Janssen Biopharma, Inc. (US) | 2020-07-07 | — | — | US | disclosed |
| US-20190314373-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | ALIOS BIOPHARMA, INC. (US) | 2019-10-17 | — | — | US | disclosed |
| US-20190248785-A1 | SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG | SHIONOGI & CO., LTD. (JP) | 2019-08-15 | — | — | US | disclosed |
| US-4064141-A | Novel esters of 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-alkanoic acids | SYNTEX (U.S.A.) INC. (US) | 1977-12-20 | — | — | US | disclosed |
| US-4055574-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, MUSCLE RELAXANT | SYNTEX (U.S.A.) INC. (US) | 1977-10-25 | — | — | US | disclosed |
| US-4003915-A | ANTICONVULSANTS, PARKINSON*S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 1977-01-18 | — | — | US | disclosed |
| US-4000288-A | ANALGESICS, ANTIINFLAMMATORY AGENTS, PYREXIA | SYNTEX (U.S.A.) INC. (US) | 1976-12-28 | — | — | US | disclosed |
| US-4000288-A | ANALGESICS, ANTIINFLAMMATORY AGENTS, PYREXIA | SYNTEX (U.S.A.) INC. (US) | 1976-12-28 | — | — | US | disclosed |
| US-4000308-A | ANTIINFLAMMATORY, ANALGESICS, ANTIPYREXIA | SYNTEX (U.S.A.) INC. (US) | 1976-12-28 | — | — | US | disclosed |
| US-4000308-A | ANTIINFLAMMATORY, ANALGESICS, ANTIPYREXIA | SYNTEX (U.S.A.) INC. (US) | 1976-12-28 | — | — | US | disclosed |
| US-3989839-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC | SYNTEX (U.S.A.) INC. (US) | 1976-11-02 | — | — | US | disclosed |
| US-3989839-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC | SYNTEX (U.S.A.) INC. (US) | 1976-11-02 | — | — | US | disclosed |
| US-3985895-A | DIURETIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1976-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190314373-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | PNPO, ITPA, PDXK | ACHE 178/4885AKR1B1 1902/4885MAOA 132/4885 |
| US-20190248785-A1 | SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG | PREP, UNG, DPP4 | ACHE 1599/4885AKR1B1 1860/4885MAOA 555/4885 |
| US-20210186969-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | PNPO, ITPA, PDXK | ACHE 178/4885AKR1B1 1902/4885MAOA 132/4885 |
| US-10702523-B2 | AZA-pyridone compounds and uses thereof | PNPO, ITPA, PDXK | ACHE 178/4885AKR1B1 1902/4885MAOA 132/4885 |
| US-20200339565-A1 | PRODRUG SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE | PREP, UNG, DPP4 | ACHE 1476/4885AKR1B1 1698/4885MAOA 575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.