SCHEMBL5667489

SCHEMBL5667489

O=C(O)c1cc(Oc2ccccc2C#Cc2cccc(-c3ccccc3)c2)cc(C(=O)O)c1

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 2/20 0.42
KMO O15229 1/20 0.41
NR4A2 P43354 1/20 0.40
AKR1C3 P42330 1/20 0.39
SLC16A3 O15427 1/20 0.39
HAO1 Q9UJM8 3/20 0.39
FABP1 P07148 1/20 0.39
LPAR1 Q92633 1/20 0.38
LPAR5 Q9H1C0 1/20 0.38
FFAR1 O14842 1/20 0.38
PTGES O14684 1/20 0.38
TTR P02766 1/20 0.37
MRGPRX4 Q96LA9 1/20 0.37
LMNA P02545 1/20 0.36
GAA P10253 1/20 0.36
RXRA P19793 1/20 0.36
RXRB P28702 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2746893 0.90 NPC1 (0.43) AKR1C3HAO1LPAR1LPAR5FFAR1
SCHEMBL5667931 0.83 FFAR1 (0.41) DHODHAKR1C3LPAR1LPAR5FFAR1
SCHEMBL5667719 0.82 KMO (0.41) KMOSLC16A3FFAR1PTGESTTR
SCHEMBL2746171 0.81 DHODH (0.44) DHODHKMONR4A2AKR1C3FABP1
SCHEMBL5669449 0.80 TTR (0.45) KMOAKR1C3LPAR1LPAR5TTR
SCHEMBL5667268 0.79 DHODH (0.49) DHODHKMOSLC16A3FFAR1RXRA
SCHEMBL2707884 0.78 DHODH (0.42) DHODHAKR1C3FABP1LPAR1LPAR5
SCHEMBL5669424 0.76 DHODH (0.58) DHODHKMOHAO1RXRARXRB
SCHEMBL5667299 0.76 LPAR1 (0.44) NR4A2AKR1C3LPAR1LPAR5TTR
SCHEMBL2746167 0.76 AKR1C3 (0.60) KMOAKR1C3HAO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1333050-B1 MATERIAL FOR INSULATING FILM, COATING VARNISH FOR INSULATING FILM, AND INSULATING FILM AND SEMICONDUCTOR DEVICE USING THE SAME SUMITOMO BAKELITE CO (JP) 2006-12-27 EP disclosed
US-7049371-B2 Material for an insulating film, coating varnish for an insulating film, and insulating film and semiconductor device using the same SUMITOMO BAKELITE COMPANY, LTD. (JP) 2006-05-23 US disclosed
US-20040002572-A1 Material for an insulating film, coating varnish for an insulating film, and insulating film and semiconductor device using the same SUMITOMO BAKELITE COMPANY, LTD. (JP) 2004-01-01 US disclosed
EP-1333050-A1 MATERIAL FOR INSULATING FILM, COATING VARNISH FOR INSULATING FILM, AND INSULATING FILM AND SEMICONDUCTOR DEVICE USING THE SAME SUMITOMO BAKELITE CO., LTD. (JP) 2003-08-06 EP disclosed