Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 5/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | VDR | P11473 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5667661 | 0.72 | CA2 (0.47) | CNR1KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL27757252 | 0.67 | PTGS2 (0.47) | CNR1KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL12613819 | 0.63 | KDM4E (0.46) | NR4A2KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4446646 | 0.62 | AKR1B1 (0.55) | — | |
| SCHEMBL10579674 | 0.61 | KDM4E (0.51) | CNR1NR4A2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2730310 | 0.58 | NR4A2 (0.62) | NR4A2KDM4EALDH1A1MEN1HPGD | |
| SCHEMBL3228523 | 0.57 | AHR (0.61) | NR4A2KDM4EALDH1A1MEN1HPGD | |
| SCHEMBL30364598 | 0.57 | ALDH1A1 (0.50) | NR4A2KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL3228514 | 0.57 | ALDH1A1 (0.50) | NR4A2KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL1021516 | 0.57 | ALDH1A1 (0.55) | NR4A2KDM4EALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1491540-B1 | Intermediates useful for the synthesis of pyridazinone aldose reductase inhibitors | PFIZER PROD INC (US) | 2006-12-13 | — | — | EP | disclosed |