SCHEMBL5667869

SCHEMBL5667869

Cc1ccc(Nc2ccc3oc4ccc(Nc5ccc(C)cc5C)cc4c3c2)c(C)c1

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.51
▸ RAPGEF4 Q8WZA2 2/20 0.49
▸ TDO2 P48775 1/20 0.44
▸ KDR P35968 1/20 0.42
▸ RAB9A P51151 2/20 0.40
▸ PTPN5 P54829 1/20 0.40
▸ MEN1 O00255 4/20 0.40
▸ KMT2A Q03164 4/20 0.40
▸ SMN1; SMN2 Q16637 2/20 0.40
▸ ALDH1A1 P00352 1/20 0.40
▸ GAA P10253 1/20 0.40
▸ POLB P06746 1/20 0.37
▸ CASP6 P55212 1/20 0.37
▸ BCL2L1 Q07817 1/20 0.37
▸ MCL1 Q07820 1/20 0.37
▸ CTDSP1 Q9GZU7 1/20 0.37
▸ TDP1 Q9NUW8 1/20 0.37
▸ L3MBTL1 Q9Y468 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23358311 0.83 LMNA (0.59) LMNARAPGEF4RAB9AMEN1KMT2A
SCHEMBL30477869 0.83 LMNA (0.59) LMNARAPGEF4RAB9AMEN1KMT2A
SCHEMBL1921159 0.80 RAPGEF4 (0.65) LMNARAPGEF4RAB9AMEN1KMT2A
SCHEMBL29445703 0.80 RAPGEF4 (0.65) LMNARAPGEF4RAB9AMEN1KMT2A
SCHEMBL30146931 0.78 RAPGEF4 (0.63) RAPGEF4RAB9AMEN1KMT2ASMN1; SMN2
SCHEMBL5667044 0.78 RAPGEF4 (0.63) RAPGEF4RAB9AMEN1KMT2ASMN1; SMN2
SCHEMBL17070724 0.77 LMNA (0.44) LMNARAPGEF4TDO2RAB9AMEN1
SCHEMBL22814249 0.77 RAPGEF4 (0.57) LMNARAPGEF4RAB9AMEN1KMT2A
SCHEMBL5028501 0.76 RAPGEF4 (0.61) RAPGEF4RAB9AMEN1KMT2ASMN1; SMN2
SCHEMBL19842081 0.75 MAPT (0.47) LMNARAB9AKMT2ASMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1394617-B1 Electrophotographic Photosensitive Member, Process Cartridge and Electrophotographic Apparatus CANON KK (JP) 2006-12-13 — — EP disclosed
US-6994941-B2 comprises bis(2,4-dimethylphenyl)amine as charge transfer compound; improved wear/scratch resistance and stability CANON KABUSHIKI KAISHA (JP) 2006-02-07 — — US disclosed
US-20050208402-A1 Electrophotographic photosensitive member, process cartridge and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2005-09-22 — — US disclosed
US-20050100805-A1 Electrophotographic photosensitive member, process cartridge and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2005-05-12 — — US disclosed
EP-1394617-A2 Electrophotographic Photosensitive Member, Process Cartridge and Electrophotographic Apparatus CANON KABUSHIKI KAISHA (JP) 2004-03-03 — — EP disclosed
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