Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29445703 | 0.87 | RAPGEF4 (0.65) | RAPGEF4SMN1; SMN2LMNAMAPTHTT | |
| SCHEMBL1921159 | 0.87 | RAPGEF4 (0.65) | RAPGEF4SMN1; SMN2LMNAMAPTHTT | |
| SCHEMBL5667044 | 0.85 | RAPGEF4 (0.63) | RAPGEF4SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL30146931 | 0.85 | RAPGEF4 (0.63) | RAPGEF4SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL5533422 | 0.84 | ALDH1A1 (0.42) | RAPGEF4SMN1; SMN2LMNAMAPTHTT | |
| SCHEMBL5028501 | 0.83 | RAPGEF4 (0.61) | RAPGEF4SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL9735309 | 0.82 | RAPGEF4 (0.46) | RAPGEF4SMN1; SMN2LMNAMAPTHTT | |
| SCHEMBL1921480 | 0.82 | RAPGEF4 (0.59) | RAPGEF4SMN1; SMN2LMNAMAPTMEN1 | |
| SCHEMBL22814211 | 0.81 | ALDH1A1 (0.46) | SMN1; SMN2LMNAMAPTHTTMEN1 | |
| SCHEMBL1334869 | 0.80 | RAPGEF4 (0.74) | RAPGEF4SMN1; SMN2LMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544984-B1 | BISBENZOFURAN-FUSED 2,8-DIAMINOINDENO[1,2-B]FLUORENE DERIVATIVES AND RELATED COMPOUNDS AS MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES (OLED) | MERCK PATENT GMBH (DE) | 2020-12-23 | — | — | EP | disclosed |