Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | KDM1A | O60341 | 5/20 | 0.52 |
| ▸ | ADH1B | P00325 | 2/20 | 0.43 |
| ▸ | ADH1C | P00326 | 2/20 | 0.43 |
| ▸ | ADH1A | P07327 | 2/20 | 0.43 |
| ▸ | ADH7 | P40394 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.43 |
| ▸ | ADH4 | P08319 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8428945 | 0.98 | KDM1A (0.56) | TSHRALDH1A1KDM1AADH1BADH1C | |
| SCHEMBL8424536 | 0.98 | KDM1A (0.56) | TSHRALDH1A1KDM1AADH1BADH1C | |
| SCHEMBL10943302 | 0.98 | KDM1A (0.56) | TSHRALDH1A1KDM1AADH1BADH1C | |
| SCHEMBL10827259 | 0.98 | KDM1A (0.56) | TSHRALDH1A1KDM1AADH1BADH1C | |
| SCHEMBL3476979 | 0.98 | KDM1A (0.56) | TSHRALDH1A1KDM1AADH1BADH1C | |
| SCHEMBL7037260 | 0.90 | PPARA (0.50) | TSHRALDH1A1KDM1APPARA | |
| SCHEMBL17734071 | 0.83 | — | — | |
| SCHEMBL27374616 | 0.80 | ALDH1A1 (0.56) | TSHRALDH1A1KDM1AADH1BADH1C | |
| SCHEMBL5884796 | 0.79 | TSHR (0.55) | TSHRALDH1A1KDM1AADH1BADH1C | |
| SCHEMBL5884803 | 0.79 | TSHR (0.55) | TSHRALDH1A1KDM1AADH1BADH1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100372532-C | Imidazolin-2-ylaminophenyl amides as IP antagonists. | HOFFMANN LA ROCHE (CH) | 2008-03-05 | — | — | CN | disclosed |
| US-7279498-B2 | Substituted aryl amides as IP antagonists | ROCHE PALO ALTO LLC (US) | 2007-10-09 | — | — | US | disclosed |
| CN-1780617-A | Imidazolin-2-ylaminophenyl amides as IP antagonists. | HOFFMANN LA ROCHE (CH) | 2006-05-31 | — | — | CN | disclosed |
| CN-1249123-C | Method for preparing nylon 6,6 | DU PONT (CH) | 2006-04-05 | — | — | CN | disclosed |
| US-6998414-B2 | Substituted arylamides as IP antagonists | ROCHE PALO ALTO LLC (US) | 2006-02-14 | — | — | US | disclosed |
| EP-1622611-A1 | IMIDAZOLIN-2-YLAMINOPHENYL AMIDES AS IP ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-02-08 | — | — | EP | disclosed |
| US-20060004075-A1 | Substituted aryl amides as IP antagonists | ROCHE PALO ALTO LLC | 2006-01-05 | — | — | US | disclosed |
| WO-2004096213-A1 | IMIDAZOLIN-2-YLAMINOPHENYL AMIDES AS IP ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-11 | — | — | WO | disclosed |
| US-20040220247-A1 | Substituted arylamides as IP antagonists | ROCHE PALO ALTO LLC | 2004-11-04 | — | — | US | disclosed |
| CN-1513016-A | Process for making nylon 6,6 | ��Ľ���Ű˾ | 2004-07-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004075-A1 | Substituted aryl amides as IP antagonists | INSR, INSRR, GIPR | TSHR 38/4885ALDH1A1 2894/4885KDM1A 3240/4885 |
| US-20040220247-A1 | Substituted arylamides as IP antagonists | INSR, PTGER1, INSRR | TSHR 144/4885ALDH1A1 2221/4885KDM1A 3306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.