Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5669620 | 1.00 | MEN1 (0.47) | MEN1KMT2AGAACA12CA1 | |
| SCHEMBL7271653 | 0.90 | MEN1 (0.55) | MEN1KMT2AGAACA12CA1 | |
| SCHEMBL6936026 | 0.90 | MEN1 (0.55) | MEN1KMT2AGAACA12CA1 | |
| SCHEMBL31492066 | 0.86 | LRRK2 (0.47) | MEN1KMT2AGAAPOLBL3MBTL1 | |
| SCHEMBL20251030 | 0.84 | AGTR1 (0.52) | MEN1KMT2AGAACA12CA1 | |
| SCHEMBL7263628 | 0.82 | KDR (0.53) | MEN1KMT2AGAACA12CA1 | |
| SCHEMBL6941860 | 0.82 | KDR (0.53) | MEN1KMT2AGAACA12CA1 | |
| SCHEMBL5427496 | 0.80 | CA1 (0.54) | CA12CA1CA9CA2MAPT | |
| SCHEMBL5427493 | 0.80 | CA1 (0.54) | CA12CA1CA9CA2MAPT | |
| SCHEMBL7269531 | 0.78 | MEN1 (0.44) | MEN1KMT2AGAACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583827-A4 | CRYSTALS AND STRUCTURES OF SPLEEN TYROSINE KINASE SYKKD | STRUCTURAL GENOMIX INC (US) | 2006-07-12 | — | — | EP | disclosed |
| EP-1631876-A2 | CRYTALS AND STRUCTURES OF C-ABL TRYOSINE KNASE DOMAIN | SGX Pharmaceuticals, Inc. (US) | 2006-03-08 | — | — | EP | disclosed |
| EP-1583827-A2 | CRYSTALS AND STRUCTURES OF SPLEEN TYROSINE KINASE SYKKD | Structural Genomix, Inc. (US) | 2005-10-12 | — | — | EP | disclosed |
| US-20050107298-A1 | crystalline forms of polypeptides that correspond to the kinase domain of c-Abl tyrosine kinase; useful, for example, for solving the crystal and solution structures of related and unrelated proteins, for screening for, identifying, and/or designing protein analogues and modified proteins | SGX PHARMACEUTICALS, INC. | 2005-05-19 | — | — | US | disclosed |
| US-20040253178-A1 | Crystals and structures of spleen tyrosine kinase SYKKD | SGX PHARMACEUTICALS, INC. | 2004-12-16 | — | — | US | disclosed |
| WO-2004107114-A2 | CRYTALS AND STRUCTURES OF C-ABL TRYOSINE KNASE DOMAIN | SGX PHARMACEUTICALS, INC. (US) | 2004-12-09 | — | — | WO | disclosed |
| WO-2004058177-A2 | CRYSTALS AND STRUCTURES OF SPLEEN TYROSINE KINASE SYKKD | STRUCTURAL GENOMIX, INC. (US) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107298-A1 | crystalline forms of polypeptides that correspond to the kinase domain of c-Abl tyrosine kinase; useful, for example, for solving the crystal and solution structures of related and unrelated proteins, for screening for, identifying, and/or designing protein analogues and modified proteins | ABL2, ABL1, SRC | MEN1 2812/4885KMT2A 1569/4885GAA 1639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.