Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | QDPR | P09417 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 6/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6672761 | 0.82 | HRH3 (0.45) | PARP1 | |
| SCHEMBL5670703 | 0.80 | HTR6 (0.40) | HTR6DRD3QDPRNAMPTHTR2C | |
| SCHEMBL2124644 | 0.79 | ESR2 (0.45) | DRD3ESR1ESR2 | |
| SCHEMBL19638276 | 0.78 | CAMK2A (0.41) | ESR1ESR2 | |
| SCHEMBL4637682 | 0.78 | NR1H2 (0.46) | ESR1ESR2 | |
| SCHEMBL2120755 | 0.77 | DPP4 (0.38) | DRD3NAMPT | |
| SCHEMBL5669983 | 0.76 | ESR2 (0.40) | ESR1ESR2 | |
| SCHEMBL5551729 | 0.76 | ESR1 (0.47) | DRD3ESR1ESR2 | |
| SCHEMBL5170173 | 0.76 | ALDH1A1 (0.34) | NAMPT | |
| SCHEMBL5170182 | 0.75 | HCRTR1 (0.32) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730114-A1 | BENZAZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005087746-A1 | BENZAZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-09-22 | — | — | WO | disclosed |