Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.45 |
| ▸ | F10 | P00742 | 4/20 | 0.44 |
| ▸ | PLG | P00747 | 4/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | BCL9 | O00512 | 2/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.36 |
| ▸ | OXTR | P30559 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6674092 | 0.86 | HRH3 (0.48) | HRH3 | |
| SCHEMBL5551729 | 0.82 | ESR1 (0.47) | — | |
| SCHEMBL5670701 | 0.82 | HTR6 (0.42) | PARP1 | |
| SCHEMBL6672764 | 0.81 | F10 (0.45) | HRH3F10PLGPRSS1PRSS2 | |
| SCHEMBL6674044 | 0.81 | F10 (0.49) | HRH3F10PLGPRSS1PRSS2 | |
| SCHEMBL2121244 | 0.80 | ESR1 (0.40) | — | |
| SCHEMBL5713459 | 0.80 | GHSR (0.44) | HRH3 | |
| SCHEMBL4637682 | 0.78 | NR1H2 (0.46) | — | |
| SCHEMBL2124644 | 0.77 | ESR2 (0.45) | — | |
| SCHEMBL5165131 | 0.76 | GRIN1 (0.54) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004035544-A1 | BENZO[D]AZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2004-04-29 | — | — | WO | disclosed |