Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 3/20 | 0.36 |
| ▸ | QDPR | P09417 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.34 |
| ▸ | SLC18A2 | Q05940 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6672764 | 0.83 | F10 (0.45) | KDM1A | |
| SCHEMBL2124647 | 0.80 | ESR1 (0.44) | ESR1SLC18A2KDM4EABCB11ALDH1A1 | |
| SCHEMBL5670701 | 0.80 | HTR6 (0.42) | HTR6DRD3ESR1QDPRNAMPT | |
| SCHEMBL4637685 | 0.79 | NR1H2 (0.39) | ESR1SLC18A2KDM4EABCB11ALDH1A1 | |
| SCHEMBL2120757 | 0.79 | PPARD (0.39) | DRD3NAMPTSLC18A2KDM4EABCB11 | |
| SCHEMBL5170176 | 0.78 | SLC18A2 (0.36) | ESR1NAMPTSLC18A2KDM4EABCB11 | |
| SCHEMBL5170187 | 0.78 | SLC18A2 (0.36) | SLC18A2KDM4EABCB11ALDH1A1POLB | |
| SCHEMBL5551732 | 0.78 | MTNR1B (0.50) | ESR1SLC18A2KDM4EABCB11ALDH1A1 | |
| SCHEMBL5669989 | 0.77 | ESR1 (0.38) | ESR1SLC18A2KDM4EABCB11ALDH1A1 | |
| SCHEMBL5243261 | 0.76 | HTR1A (0.41) | NAMPTHTR2CALDH1A1HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730114-A1 | BENZAZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005087746-A1 | BENZAZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-09-22 | — | — | WO | disclosed |