Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | ALPL | P05186 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | ALPI | P09923 | 3/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA3 | P07451 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13813786 | 0.82 | ALPL (0.55) | MAOBKDM4EALPLALDH1A1HPGD | |
| SCHEMBL3918843 | 0.82 | MEN1 (0.49) | MAOBALPLALDH1A1ALPICA12 | |
| SCHEMBL5671449 | 0.81 | MAOB (0.45) | MAOBKDM4EALPLALDH1A1ALPI | |
| SCHEMBL13930283 | 0.80 | MAOB (0.71) | MAOBKDM4EALPLALDH1A1HPGD | |
| SCHEMBL30803821 | 0.78 | KDM4E (0.76) | KDM4EALDH1A1HPGDHSD17B10GLA | |
| SCHEMBL11511686 | 0.78 | KDM4E (0.76) | KDM4EALDH1A1HPGDHSD17B10GLA | |
| SCHEMBL15442934 | 0.78 | ALDH1A1 (0.51) | MAOBKDM4EALPLALDH1A1HPGD | |
| SCHEMBL3553197 | 0.78 | KDM4E (0.55) | KDM4EALDH1A1HPGDHSD17B10GLA | |
| SCHEMBL30231652 | 0.78 | KDM4E (0.55) | KDM4EALDH1A1HPGDHSD17B10GLA | |
| SCHEMBL13930281 | 0.77 | PIM1 (0.46) | MAOBKDM4EALPLALDH1A1ALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7148253-B2 | 4-thio coumarins | XTL BIOPHARMACEUTICALS LTD. (IL) | 2006-12-12 | — | — | US | disclosed |
| EP-1504000-A4 | 4-THIO COUMARINS | VIVOQUEST INC (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005068450-A1 | 4-THIO COUMARINS | VIVOQUEST, INC. (US) | 2005-07-28 | — | — | WO | disclosed |
| EP-1504000-A1 | 4-THIO COUMARINS | Vivoquest, Inc. (US) | 2005-02-09 | — | — | EP | disclosed |
| US-20040180950-A1 | 4-Thio coumarins | PRESIDIO PHARMACEUTICALS, INC. | 2004-09-16 | — | — | US | disclosed |
| US-6703514-B2 | BIOLOGICAL SCREENING | VIVO QUEST, INC. | 2004-03-09 | — | — | US | disclosed |
| US-20040002538-A1 | Drug screening; forming libraries; solid phase biosynthesis | PRESIDIO PHARMACEUTICALS, INC. | 2004-01-01 | — | — | US | disclosed |
| WO-2003097628-A1 | 4-THIO COUMARINS | VIVOQUEST, INC. (US) | 2003-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040002538-A1 | Drug screening; forming libraries; solid phase biosynthesis | COASY, FDPS, CYP4F3 | MAOB 2164/4885KDM4E 2454/4885ALPL 3806/4885 |
| US-20040180950-A1 | 4-Thio coumarins | CYP3A4, HAVCR2, CYP4B1 | MAOB 3577/4885KDM4E 3748/4885ALPL 3166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.