Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 11/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ATF4 | P18848 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5116283 | 0.88 | SMN1; SMN2 (0.54) | MCHR1LMNAATF4CYP1A2CYP3A4 | |
| SCHEMBL5124087 | 0.86 | MCHR1 (0.61) | MCHR1ATF4CHRM1CHRM3CYP1A2 | |
| SCHEMBL5122821 | 0.86 | LMNA (0.58) | LMNAATF4CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL17658754 | 0.80 | ATF4 (0.74) | MCHR1LMNAATF4CYP1A2CYP3A4 | |
| SCHEMBL5670333 | 0.78 | MCHR1 (0.51) | MCHR1ATF4CHRM1CHRM3CYP1A2 | |
| SCHEMBL5671614 | 0.78 | HTR1A (0.37) | MCHR1CHRM1CHRM3 | |
| SCHEMBL4668785 | 0.76 | MCHR1 (0.55) | MCHR1ATF4KCNH2 | |
| SCHEMBL4668786 | 0.76 | MCHR1 (0.55) | MCHR1ATF4KCNH2 | |
| SCHEMBL4033699 | 0.75 | ATF4 (0.81) | LMNAATF4 | |
| SCHEMBL5123998 | 0.75 | POLB (0.62) | LMNAATF4CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730136-A1 | N-PIPERIDINE DERIVATES AS CCR3 MODULATORS | AstraZeneca AB (SE) | 2006-12-13 | — | — | EP | claimed |
| WO-2005090330-A1 | N-PIPERIDINE DERIVATES AS CCR3 MODULATORS | ASTRAZENECA AB (SE) | 2005-09-29 | — | — | WO | claimed |
| EP-1730136-A1 | N-PIPERIDINE DERIVATES AS CCR3 MODULATORS | AstraZeneca AB (SE) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005090330-A1 | N-PIPERIDINE DERIVATES AS CCR3 MODULATORS | ASTRAZENECA AB (SE) | 2005-09-29 | — | — | WO | disclosed |