Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ESRRG | P62508 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5674543 | 0.81 | CALM1 (0.46) | KCNH2 | |
| SCHEMBL5671609 | 0.79 | L3MBTL1 (0.41) | SIGMAR1 | |
| SCHEMBL5673067 | 0.77 | SIGMAR1 (0.42) | SIGMAR1 | |
| SCHEMBL31573982 | 0.74 | KCNH2 (0.67) | KCNH2SIGMAR1LMNAESRRGNR1H4 | |
| SCHEMBL8956085 | 0.74 | KCNH2 (0.53) | KCNH2SIGMAR1LMNAESRRGNR1H4 | |
| SCHEMBL1611465 | 0.74 | KCNH2 (0.53) | KCNH2SIGMAR1LMNAESRRGNR1H4 | |
| SCHEMBL1068676 | 0.74 | KCNH2 (0.53) | KCNH2SIGMAR1LMNAESRRGNR1H4 | |
| SCHEMBL5671669 | 0.73 | GPR52 (0.37) | LMNA | |
| SCHEMBL15307342 | 0.72 | — | — | |
| SCHEMBL5671598 | 0.71 | TAAR1 (0.44) | KCNH2SIGMAR1TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578717-A4 | NITRONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND METHODS FOR TREATING INFLAMMATION AND NEUROPATHIC PAIN | RENOVIS INC (US) | 2006-08-09 | — | — | EP | disclosed |
| EP-1578717-A2 | NITRONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND METHODS FOR TREATING INFLAMMATION AND NEUROPATHIC PAIN | Renovis, Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004034999-A2 | NITRONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND METHODS FOR TREATING INFLAMMATION AND NEUROPATHIC PAIN | RENOVIS, INC. (US) | 2004-04-29 | — | — | WO | disclosed |