Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.40 |
| ▸ | FLT4 | P35916 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7490542 | 1.00 | TDP1 (0.43) | TDP1FLT1FLT4KDRHSD11B1 | |
| SCHEMBL5672285 | 0.93 | TDP1 (0.40) | TDP1HSD11B1MEN1KMT2AENPP3 | |
| SCHEMBL7495927 | 0.93 | TDP1 (0.40) | TDP1HSD11B1MEN1KMT2AENPP3 | |
| SCHEMBL5673248 | 0.89 | KMT2A (0.41) | TDP1HSD11B1KMT2AALDH1A1LMNA | |
| SCHEMBL5672253 | 0.89 | KMT2A (0.41) | TDP1HSD11B1KMT2AALDH1A1LMNA | |
| SCHEMBL31316 | 0.85 | HSD11B1 (0.43) | HSD11B1KMT2AMMP2ALDH1A1KEAP1 | |
| SCHEMBL31317 | 0.85 | HSD11B1 (0.43) | HSD11B1KMT2AMMP2ALDH1A1KEAP1 | |
| SCHEMBL14141983 | 0.85 | HSD11B1 (0.43) | HSD11B1KMT2AMMP2ALDH1A1KEAP1 | |
| SCHEMBL5120356 | 0.85 | HSD11B1 (0.43) | HSD11B1KMT2AMMP2ALDH1A1KEAP1 | |
| SCHEMBL6139230 | 0.85 | PSEN1 (0.43) | TDP1FLT1FLT4KDRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030208077-A1 | Hydroxyacetic ester derivatives, preparation method and use as synthesis intermediates | SANOFI (FR) | 2003-11-06 | — | — | US | claimed |
| EP-1021449-B1 | HYDROXYACETIC ESTER DERIVATIVES, PREPARATION METHOD AND USE AS SYNTHESIS INTERMEDIATES | SANOFI SYNTHELABO (FR) | 2002-01-02 | — | — | EP | claimed |
| EP-1021449-A1 | HYDROXYACETIC ESTER DERIVATIVES, PREPARATION METHOD AND USE AS SYNTHESIS INTERMEDIATES | SANOFI-SYNTHELABO (FR) | 2000-07-26 | — | — | EP | claimed |
| WO-1999018110-A1 | HYDROXYACETIC ESTER DERIVATIVES, PREPARATION METHOD AND USE AS SYNTHESIS INTERMEDIATES | SANOFI-SYNTHELABO (FR) | 1999-04-15 | — | — | WO | claimed |
| US-7153969-B2 | Hydroxyacetic ester derivatives, preparation method and use as synthesis intermediates | SANOFI-AVENTIS (FR) | 2006-12-26 | — | — | US | disclosed |
| US-6894186-B2 | Hydroxyacetic ester derivatives, preparation method and use as synthesis intermediates | SANOFI-SYNTHELABO (FR) | 2005-05-17 | — | — | US | disclosed |
| US-20040260110-A1 | Hydroxyacetic ester derivatives, preparation method and use as synthesis intermediates | SANOFI (FR) | 2004-12-23 | — | — | US | disclosed |
| US-20030208077-A1 | Hydroxyacetic ester derivatives, preparation method and use as synthesis intermediates | SANOFI (FR) | 2003-11-06 | — | — | US | disclosed |
| US-6573381-B1 | Useful as intermediates, notably for the synthesis of methyl (S)-2(2-chlorophenyl)-2(4,5,6,7-tetrahydrothieno(3,2-c)-5-pyridyl)acetate or clopidrogel | SANOFI-SYNTHELABO (FR) | 2003-06-03 | — | — | US | disclosed |
| EP-1021449-B1 | HYDROXYACETIC ESTER DERIVATIVES, PREPARATION METHOD AND USE AS SYNTHESIS INTERMEDIATES | SANOFI SYNTHELABO (FR) | 2002-01-02 | — | — | EP | disclosed |
| EP-1021449-A1 | HYDROXYACETIC ESTER DERIVATIVES, PREPARATION METHOD AND USE AS SYNTHESIS INTERMEDIATES | SANOFI-SYNTHELABO (FR) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999018110-A1 | HYDROXYACETIC ESTER DERIVATIVES, PREPARATION METHOD AND USE AS SYNTHESIS INTERMEDIATES | SANOFI-SYNTHELABO (FR) | 1999-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030208077-A1 | Hydroxyacetic ester derivatives, preparation method and use as synthesis intermediates | HAAO, HTR3C, HTR3A | TDP1 2832/4885FLT1 4161/4885FLT4 3028/4885 |
| US-20040260110-A1 | Hydroxyacetic ester derivatives, preparation method and use as synthesis intermediates | HAAO, HTR3C, HTR3A | TDP1 2832/4885FLT1 4161/4885FLT4 3028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.