⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2687153 | 0.72 | LMNA (0.31) | — | |
| SCHEMBL11666000 | 0.70 | HSD17B3 (0.53) | — | |
| SCHEMBL6538147 | 0.68 | — | — | |
| SCHEMBL15252356 | 0.65 | CRBN (0.37) | — | |
| Squamolone SCHEMBL1051735 | 0.64 | — | — | |
| Squamolone SCHEMBL28367081 | 0.63 | LMNA (0.57) | — | |
| SCHEMBL4697679 | 0.63 | — | — | |
| SCHEMBL4702017 | 0.63 | LMNA (0.52) | — | |
| SCHEMBL5240878 | 0.61 | — | — | |
| SCHEMBL1424272 | 0.61 | LMNA (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511745-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2006-11-15 | — | — | EP | disclosed |
| EP-1511745-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2006-11-15 | — | — | EP | disclosed |
| US-20050256100-A1 | Protease inhibitors | JEONG JAE U | 2005-11-17 | — | — | US | disclosed |
| US-20050256100-A1 | Protease inhibitors | JEONG JAE U | 2005-11-17 | — | — | US | disclosed |
| EP-1511745-A2 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-03-09 | — | — | EP | disclosed |
| EP-1511745-A2 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003097593-A3 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-07-08 | — | — | WO | disclosed |
| WO-2003097593-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-11-27 | — | — | WO | disclosed |
| WO-2003097593-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-11-27 | — | — | WO | disclosed |