SCHEMBL5672111

SCHEMBL5672111

COC(=O)c1ccc(-c2ccc3c(c2)CCN(C(=O)O)CC3CC(C)C)nc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 3/20 0.37
HRH3 Q9Y5N1 1/20 0.36
MAPK1 P28482 4/20 0.35
TSHR P16473 3/20 0.35
ALDH1A1 P00352 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
RECQL P46063 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
HPGDS O60760 1/20 0.34
ADRB1 P08588 1/20 0.34
ADRB3 P13945 1/20 0.34
KMT2A Q03164 2/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
SLC18A2 Q05940 2/20 0.34
PLA2G1B P04054 1/20 0.34
ATG4B Q9Y4P1 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5713479 0.84 HRH3 (0.46) TP53HRH3
SCHEMBL5170957 0.84 CHRNB2 (0.38) TP53HRH3SLC18A2POLB
SCHEMBL5672109 0.83 HPGDS (0.36) MAPK1TSHRALDH1A1CYP1A2CYP3A4
SCHEMBL5669989 0.77 ESR1 (0.38) MAPK1TSHRALDH1A1SMN1; SMN2KMT2A
SCHEMBL6225110 0.77 TP53 (0.40) TP53MAPK1TSHRALDH1A1CYP1A2
SCHEMBL5170766 0.77 SMO (0.34) TP53HRH3MAPK1TSHRALDH1A1
SCHEMBL5551732 0.76 MTNR1B (0.50) MAPK1TSHRALDH1A1SLC18A2HPGD
SCHEMBL5158952 0.76 HRH3 (0.43) TP53HRH3
SCHEMBL2122938 0.76 SNCA (0.37) MAPK1TSHRALDH1A1SLC18A2HPGD
SCHEMBL2121107 0.75 PPARD (0.44) HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1730114-A1 BENZAZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS GLAXO GROUP LIMITED (GB) 2006-12-13 EP disclosed
WO-2005087746-A1 BENZAZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS GLAXO GROUP LIMITED (GB) 2005-09-22 WO disclosed