Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | MAOB | P27338 | 13/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | PKM | P14618 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | MAOA | P21397 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | ACHE | P22303 | 5/20 | 0.61 |
| ▸ | F12 | P00748 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037662 | 0.83 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL28563825 | 0.81 | SMN1; SMN2 (0.74) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL5673652 | 0.80 | ACHE (0.67) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL893303 | 0.77 | KDM4E (1.00) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL4511180 | 0.76 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL11396751 | 0.76 | MAOB (0.71) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL28682651 | 0.75 | MAOB (0.70) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL13779379 | 0.75 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL11391879 | 0.74 | SMN1; SMN2 (0.73) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL21788606 | 0.74 | HDAC2 (0.73) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081468-B2 | Ortho-substituted anthranilic acid amides and their use as medicaments | SCHERING AG (DE) | 2006-07-25 | — | — | US | disclosed |
| US-20060014747-A1 | Ortho-substituted anthranilic acid amides and their use as pharmaceutical agents | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2006-01-19 | — | — | US | disclosed |
| US-20040102441-A1 | Ortho-substituted anthranilic acid amides and their use as medicaments | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2004-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014747-A1 | Ortho-substituted anthranilic acid amides and their use as pharmaceutical agents | VEGFA, TEK, OGFR | NPC1 2536/4885RAB9A 807/4885SMN1; SMN2 2807/4885 |
| US-20040102441-A1 | Ortho-substituted anthranilic acid amides and their use as medicaments | TEK, VEGFA, ASPH | NPC1 3307/4885RAB9A 2025/4885SMN1; SMN2 2980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.