Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | LDHA | P00338 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5673042 | 0.81 | TP53 (0.58) | TP53TSHRALDH1A1SMN1; SMN2SIGMAR1 | |
| SCHEMBL5671598 | 0.72 | TAAR1 (0.44) | TP53TSHRALDH1A1CYP3A4ALOX15 | |
| SCHEMBL9900714 | 0.72 | SLC6A4 (0.58) | SLC6A4LDHACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL8283115 | 0.72 | SLC6A4 (0.58) | SLC6A4LDHACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL113550 | 0.72 | SLC6A4 (0.58) | SLC6A4LDHACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL30290019 | 0.72 | SLC6A4 (0.58) | SLC6A4LDHACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL15314133 | 0.70 | SLC6A4 (0.56) | SLC6A4LDHACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5674543 | 0.70 | CALM1 (0.46) | ALOX15 | |
| SCHEMBL12776284 | 0.70 | SLC6A4 (0.60) | SLC6A4LDHACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL19559508 | 0.69 | SLC6A4 (0.55) | SLC6A4LDHACYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115666-B2 | Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain | RENOVIS, INC. (US) | 2006-10-03 | — | — | US | claimed |
| EP-1578717-A4 | NITRONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND METHODS FOR TREATING INFLAMMATION AND NEUROPATHIC PAIN | RENOVIS INC (US) | 2006-08-09 | — | — | EP | claimed |
| EP-1578717-A2 | NITRONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND METHODS FOR TREATING INFLAMMATION AND NEUROPATHIC PAIN | Renovis, Inc. (US) | 2005-09-28 | — | — | EP | claimed |
| WO-2004034999-A2 | NITRONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND METHODS FOR TREATING INFLAMMATION AND NEUROPATHIC PAIN | RENOVIS, INC. (US) | 2004-04-29 | — | — | WO | claimed |
| US-7115666-B2 | Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain | RENOVIS, INC. (US) | 2006-10-03 | — | — | US | disclosed |
| EP-1578717-A4 | NITRONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND METHODS FOR TREATING INFLAMMATION AND NEUROPATHIC PAIN | RENOVIS INC (US) | 2006-08-09 | — | — | EP | disclosed |
| US-20060100289-A1 | Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain | RENOVIS, INC. | 2006-05-11 | — | — | US | disclosed |
| EP-1578717-A2 | NITRONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND METHODS FOR TREATING INFLAMMATION AND NEUROPATHIC PAIN | Renovis, Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004034999-A2 | NITRONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND METHODS FOR TREATING INFLAMMATION AND NEUROPATHIC PAIN | RENOVIS, INC. (US) | 2004-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100289-A1 | Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain | MMP8, PTGES, NGF | SLC6A4 2648/4885LDHA 1991/4885CYP1A2 797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.