Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 2/20 | 0.51 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CCR9 | P51686 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | FABP3 | P05413 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20048466 | 0.85 | CCR2 (0.51) | CMA1CCR2CCR9KDM4EKMT2A | |
| SCHEMBL5672246 | 0.79 | PRMT5 (0.38) | CCR2ALDH1A1CCR9KDM4EMAPT | |
| SCHEMBL5672286 | 0.78 | CCR2 (0.37) | CCR2ALDH1A1CCR9KDM4EMAPT | |
| SCHEMBL20853335 | 0.77 | CASR (0.42) | ALDH1A1KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL10674441 | 0.76 | ALDH1A1 (0.66) | CMA1ALDH1A1KDM4EFABP3FABP4 | |
| SCHEMBL5673158 | 0.75 | LMNA (0.44) | CCR2ALDH1A1CCR9MAPK1KDM4E | |
| SCHEMBL20037332 | 0.75 | TSHR (0.56) | ALDH1A1KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL476703 | 0.74 | CCR2 (0.35) | CMA1CCR2ALDH1A1CCR9KDM4E | |
| SCHEMBL15971121 | 0.74 | NOTUM (0.42) | CCR2ALDH1A1CCR9KDM4EMAPT | |
| SCHEMBL20853011 | 0.73 | CCR2 (0.38) | CCR2ALDH1A1CCR9KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6995184-B2 | Such as (7-chloro-2-methyl-1-(3-(methylsulphanyl)propyl)-1H-indol-3-yl)(2,3-dichloro-phenyl)methanone; cannabinoid receptors (cb2); G proteins coupled receptors | SANOFI-AVENTIS (FR) | 2006-02-07 | — | — | US | disclosed |
| CN-1234688-C | 3-aroyl indoles and their use as CB2Use of receptor agonists | SANOFI ANVANT (FR) | 2006-01-04 | — | — | CN | disclosed |
| CN-1483023-A | 3-arylindole derivatives and their use as cb2 receptor agonists | ʥŵ��-�ϳ�ʵ���ҹ�˾ | 2004-03-17 | — | — | CN | disclosed |
| US-20040034090-A1 | 3-Arylindole derivatives and their use as cb2 receptor agonists | SANOFI-AVENTIS (FR) | 2004-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034090-A1 | 3-Arylindole derivatives and their use as cb2 receptor agonists | CNR2, CNR1, GPR52 | CMA1 1674/4885CCR2 148/4885ALDH1A1 1071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.