Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.63 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.63 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.63 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.63 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.63 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.63 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.63 |
| ▸ | PRCP | P42785 | 1/20 | 0.63 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.63 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.63 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.61 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.61 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5674113 | 0.82 | SIGMAR1 (0.63) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| Phencyclidine SCHEMBL9431514 | 0.79 | SIGMAR1 (0.92) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL9129917 | 0.78 | SIGMAR1 (0.58) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL9129387 | 0.78 | SIGMAR1 (0.58) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL9153279 | 0.78 | SIGMAR1 (1.00) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| Phencyclidine SCHEMBL17008793 | 0.78 | SIGMAR1 (1.00) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| Phencyclidine SCHEMBL42022 | 0.78 | SIGMAR1 (1.00) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| Rolicyclidine SCHEMBL517928 | 0.78 | SIGMAR1 (1.00) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL3407261 | 0.78 | GRIN1 (0.92) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL4111549 | 0.78 | SIGMAR1 (0.66) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370529-B1 | SUBSTITUTED DIMETHYL- 1-(1-PHENYL-CYCLOHEXYL)-PIPERIDIN-3-YL METHYL]-AMINES AND THE USE OF THE SAME AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2006-01-11 | — | — | EP | disclosed |
| EP-1370529-A1 | SUBSTITUTED DIMETHYL- 1-(1-PHENYL-CYCLOHEXYL)-PIPERIDIN-3-YL METHYL]-AMINES AND THE USE OF THE SAME AS ANALGESICS | Grünenthal GmbH (DE) | 2003-12-17 | — | — | EP | disclosed |