Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | METAP2 | P50579 | 3/20 | 0.56 |
| ▸ | METAP1 | P53582 | 3/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MMP2 | P08253 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | GMNN | O75496 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | MMP9 | P14780 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | MMP8 | P22894 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6750955 | 0.83 | KDM4E (0.58) | KDM4ELMNAMETAP2METAP1HDAC6 | |
| SCHEMBL4386263 | 0.83 | KDM4E (0.72) | KDM4ELMNAMETAP2METAP1HDAC6 | |
| SCHEMBL28342440 | 0.82 | KDM4E (0.56) | KDM4ELMNAMETAP2METAP1HDAC6 | |
| Hydrochloric Acid SCHEMBL27496748 | 0.81 | KDM4E (0.59) | KDM4ELMNAMETAP2METAP1HDAC6 | |
| SCHEMBL17924042 | 0.79 | MAPT (0.59) | KDM4ELMNAMETAP2METAP1HDAC6 | |
| SCHEMBL6516869 | 0.79 | KDM4E (0.58) | KDM4ELMNAMETAP2METAP1HDAC6 | |
| SCHEMBL1878470 | 0.79 | KDM4E (0.58) | KDM4ELMNAMETAP2METAP1HDAC6 | |
| SCHEMBL22772422 | 0.79 | KDM4E (0.58) | KDM4ELMNAMETAP2METAP1HDAC6 | |
| SCHEMBL21753772 | 0.79 | KDM4E (0.58) | KDM4ELMNAMETAP2METAP1HDAC6 | |
| SCHEMBL170428 | 0.79 | MEN1 (0.68) | KDM4ELMNARAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644419-A1 | OLEFIN POLYMERIZATION WITH PYRIDINE MOIETY-CONTAINING SINGLE-SITE CATALYSTS | Equistar Chemicals, LP (US) | 2006-04-12 | — | — | EP | claimed |
| EP-1059310-B1 | Polymerization of alpha-olefins with transition metal catalyst based on bidentate ligands containing pyridine or quinoline moiety | EQUISTAR CHEM LP (US) | 2006-01-11 | — | — | EP | claimed |
| WO-2005007708-A1 | OLEFIN POLYMERIZATION WITH PYRIDINE MOIETY-CONTAINING SINGLE-SITE CATALYSTS | EQUISTAR CHEMICALS, LP (US) | 2005-01-27 | — | — | WO | claimed |
| US-6767975-B1 | IN PRESENCE OF CLAY, ACTIVATOR, AND TRANSITION METAL COMPLEX; ADDITION POLYMERIZATION OF ULTRA-HIGH MOLECULAR WEIGHT POLYETHYLENE; BULK DENSITY | EQUISTAR CHEMICALS, LP | 2004-07-27 | — | — | US | claimed |
| US-6635728-B2 | Preparation of ultra-high-molecular-weight polyethylene | EQUISTAR CHEMICALS, LP | 2003-10-21 | — | — | US | claimed |
| WO-2003059968-A1 | PREPARATION OF ULTRA-HIGH-MOLECULAR-WEIGHT POLYETHYLENE | EQUISTAR CHEMICALS, LP (US) | 2003-07-24 | — | — | WO | claimed |
| US-20030130448-A1 | PREPARATION OF ULTRA-HIGH-MOLECULAR-WEIGHT POLYETHYLENE | EQUISTAR CHEMICALS, LP | 2003-07-10 | — | — | US | claimed |
| EP-1059310-A2 | Polymerization of alpha-olefins with transition metal catalyst based on bidentate ligands containing pyridine or quinoline moiety | Equistar Chemicals, LP. (US) | 2000-12-13 | — | — | EP | claimed |
| US-5637660-A | Polymerization of α-olefins with transition metal catalysts based on bidentate ligands containing pyridine or quinoline moiety | LYONDELL PETROCHEMICAL COMPANY (US) | 1997-06-10 | — | — | US | claimed |
| US-7091272-B2 | Olefin polymerization with pyridine moiety-containing single-site catalysts | EQUISTAR CHEMICALS, LP (US) | 2006-08-15 | — | — | US | disclosed |
| EP-1644419-A1 | OLEFIN POLYMERIZATION WITH PYRIDINE MOIETY-CONTAINING SINGLE-SITE CATALYSTS | Equistar Chemicals, LP (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005007708-A1 | OLEFIN POLYMERIZATION WITH PYRIDINE MOIETY-CONTAINING SINGLE-SITE CATALYSTS | EQUISTAR CHEMICALS, LP (US) | 2005-01-27 | — | — | WO | disclosed |
| US-20050014915-A1 | Olefin polymerization with pyridine moiety-containing single-site catalysts | EQUISTAR CHEMICALS, LP | 2005-01-20 | — | — | US | disclosed |
| US-6790805-B2 | COORDINATION CATALYST | EQUISTAR CHEMICALS, LP | 2004-09-14 | — | — | US | disclosed |
| EP-1189698-A1 | PROCESS FOR THE IN-SITU PREPARATION OF SINGLE-SITE TRANSITION METAL CATALYSTS AND POLYMERIZATION PROCESS | Equistar Chemicals L.P. (US) | 2002-03-27 | — | — | EP | disclosed |
| US-20020010075-A1 | Process for the in-situ preparation of single-site transition metal catalysts and polymerization process | EQUISTAR CHEMICALS, LP | 2002-01-24 | — | — | US | disclosed |
| US-6291386-B1 | Process for the in-situ preparation of single-site transition metal catalysts and polymerization process | EQUISTAR CHEMICALS, LP | 2001-09-18 | — | — | US | disclosed |
| US-6239239-B1 | IMPROVED CATALYST FOR POLYMERIZING OLEFINS | EQUISTAR CHEMICALS, L.P. | 2001-05-29 | — | — | US | disclosed |
| WO-2000071251-A1 | PROCESS FOR THE IN-SITU PREPARATION OF SINGLE-SITE TRANSITION METAL CATALYSTS AND POLYMERIZATION PROCESS | EQUISTAR CHEMICALS, L.P. (US) | 2000-11-30 | — | — | WO | disclosed |
| US-6020493-A | Single-site catalyst preparation | EQUISTAR CHEMICALS, LP (US) | 2000-02-01 | — | — | US | disclosed |