Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | RAD52 | P43351 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 9/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5672469 | 0.93 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDPOLBRAD52 | |
| SCHEMBL5672855 | 0.89 | MAPT (0.54) | ALDH1A1KDM4EHPGDPOLBRAD52 | |
| SCHEMBL5672451 | 0.89 | KDM4E (0.54) | ALDH1A1KDM4EHPGDPOLBRAD52 | |
| SCHEMBL5672519 | 0.88 | MAPT (0.64) | ALDH1A1KDM4EHPGDKMT2ARAB9A | |
| SCHEMBL5673533 | 0.87 | ALDH1A1 (0.63) | ALDH1A1KDM4EHPGDPOLBRAD52 | |
| SCHEMBL5672821 | 0.85 | ALDH1A1 (0.58) | ALDH1A1KDM4EHPGDPOLBRAD52 | |
| SCHEMBL5675335 | 0.85 | KDM4E (0.61) | ALDH1A1KDM4EHPGDKMT2ARAB9A | |
| SCHEMBL5672771 | 0.84 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDPOLBRAD52 | |
| SCHEMBL5672504 | 0.84 | ALDH1A1 (0.60) | ALDH1A1KDM4EHPGDPOLBRAD52 | |
| SCHEMBL5672794 | 0.83 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDPOLBRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7009053-B2 | Quinoline derivatives as caspase-3 inhibitor, preparation for producing the same and pharmaceutical composition comprising the same | Yungjin Pharmaceuticals Co., Ltd. (KR) | 2006-03-07 | — | — | US | claimed |
| EP-1499593-A4 | QUINOLINE DERIVATIVES AS CASPASE-3 INHIBITOR, PREPARATION FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | YUNGJIN PHARMACAUTICAL CO LTD (KR) | 2006-02-01 | — | — | EP | claimed |
| EP-1499593-A1 | QUINOLINE DERIVATIVES AS CASPASE-3 INHIBITOR, PREPARATION FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Yungjin Pharmacautical Co., Ltd. (KR) | 2005-01-26 | — | — | EP | claimed |
| US-20040260094-A1 | Quinoline derivatives as caspase-3 inhibitor, preparation for producing the same and pharmaceutical composition comprising the same | YUNGJIN PHARMACEUTICAL CO., LTD. (KR) | 2004-12-23 | — | — | US | claimed |
| WO-2003093240-A1 | QUINOLINE DERIVATIVES AS CASPASE-3 INHIBITOR, PREPARATION FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | YUNGJIN PHARMACEUTICAL CO., LTD. (KR) | 2003-11-13 | — | — | WO | claimed |
| CN-1304374-C | Quinoline derivatives as caspase-3 inhibitor, preparation for producing the same and pharmaceutical composition comprising the same | YUNGJIN PHARMACEUTICAL CO LTD (KR) | 2007-03-14 | — | — | CN | disclosed |
| US-7009053-B2 | Quinoline derivatives as caspase-3 inhibitor, preparation for producing the same and pharmaceutical composition comprising the same | Yungjin Pharmaceuticals Co., Ltd. (KR) | 2006-03-07 | — | — | US | disclosed |
| EP-1499593-A4 | QUINOLINE DERIVATIVES AS CASPASE-3 INHIBITOR, PREPARATION FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | YUNGJIN PHARMACAUTICAL CO LTD (KR) | 2006-02-01 | — | — | EP | disclosed |
| CN-1662505-A | Quinoline derivatives useful as caspase-3 inhibitors, process for their preparation and pharmaceutical compositions containing them | YUNGJIN PHARMACEUTICAL CO LTD (KR) | 2005-08-31 | — | — | CN | disclosed |
| EP-1499593-A1 | QUINOLINE DERIVATIVES AS CASPASE-3 INHIBITOR, PREPARATION FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Yungjin Pharmacautical Co., Ltd. (KR) | 2005-01-26 | — | — | EP | disclosed |
| US-20040260094-A1 | Quinoline derivatives as caspase-3 inhibitor, preparation for producing the same and pharmaceutical composition comprising the same | YUNGJIN PHARMACEUTICAL CO., LTD. (KR) | 2004-12-23 | — | — | US | disclosed |
| WO-2003093240-A1 | QUINOLINE DERIVATIVES AS CASPASE-3 INHIBITOR, PREPARATION FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | YUNGJIN PHARMACEUTICAL CO., LTD. (KR) | 2003-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040260094-A1 | Quinoline derivatives as caspase-3 inhibitor, preparation for producing the same and pharmaceutical composition comprising the same | CASP1, CASP3, CASP2 | ALDH1A1 1990/4885KDM4E 1702/4885HPGD 3184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.