Water

Water

SCHEMBL5676501

N#[N+]c1ccccc1Br.[OH-]

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.36
MAPK1 P28482 1/20 0.33
MGLL Q99685 1/20 0.32
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA4 P22748 1/20 0.31
CA6 P23280 1/20 0.31
TDP1 Q9NUW8 1/20 0.30
GAA P10253 1/20 0.30
TAAR1 Q96RJ0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL972024 0.97
Fluoride Ion SCHEMBL11777456 0.95 ALDH1A1 (0.36) ALDH1A1MAPK1MGLLCA1CA2
Hydrochloric Acid SCHEMBL8459940 0.95 ALDH1A1 (0.36) ALDH1A1MAPK1MGLLCA1CA2
SCHEMBL2155974 0.88 ALDH1A1 (0.34) ALDH1A1MAPK1
SCHEMBL27846605 0.84 ALDH1A1 (0.33) ALDH1A1MGLLCA1CA2CA4
SCHEMBL5674662 0.84 ALDH1A1 (0.30) ALDH1A1
Acetic Acid SCHEMBL27752333 0.81 GAA (0.33) ALDH1A1CA1CA2CA4GAA
SCHEMBL973757 0.77
SCHEMBL5551583 0.76 CYP2A6 (0.31)
SCHEMBL9619110 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0894102-B8 COPOLYMERS OF HIGH VINYLIDENE POLYOLEFINS WITH VINYL OR VINYLIDENE MONOMERS PRODUCED BY FREE RADICAL POLYMERIZATION O & D USA LLC (US) 2006-01-18 EP disclosed
CN-1157454-C Adhesive containing copolymer of macromonomer and unsaturated acid or anhydride 埃克森美孚化学专利公司 2004-07-14 CN disclosed
EP-1141042-A1 IMPROVED PROCESS FOR MAKING POLYALKYLENE/MALEIC AHYDRIDE COPOLYMER Chevron Oronite Company LLC (US) 2001-10-10 EP disclosed
EP-1027411-A4 COPOLYMERS OF ETHYLENE $g(a)-OLEFIN MACROMERS AND DICARBOXYLIC MONOMERS AND DERIVATIVES THEREOF, USEFUL AS ADDITIVES IN LUBRICATING OILS AND IN FUELS EXXONMOBIL CHEM PATENTS INC (US) 2001-10-10 EP disclosed
WO-2001034663-A1 IMPROVED PROCESS FOR MAKING POLYALKYLENE/MALEIC AHYDRIDE COPOLYMER CHEVRON ORONITE COMPANY LLC (US) 2001-05-17 WO disclosed
CN-1272867-A Adhesive comprising copolymers of macromonomers and unsaturated acids or anhydrides EXXON CHEMICAL PATENTS INC (US) 2000-11-08 CN disclosed
EP-1027411-A1 COPOLYMERS OF ETHYLENE $g(a)-OLEFIN MACROMERS AND DICARBOXYLIC MONOMERS AND DERIVATIVES THEREOF, USEFUL AS ADDITIVES IN LUBRICATING OILS AND IN FUELS EXXON CHEMICAL PATENTS INC. (US) 2000-08-16 EP disclosed
WO-1999016851-A1 COPOLYMERS OF ETHYLENE α-OLEFIN MACROMERS AND DICARBOXYLIC MONOMERS AND DERIVATIVES THEREOF, USEFUL AS ADDITIVES IN LUBRICATING OILS AND IN FUELS EXXON CHEMICAL PATENTS INC. (US) 1999-04-08 WO disclosed
EP-0894102-A1 COPOLYMERS OF HIGH VINYLIDENE POLYOLEFINS WITH VINYL OR VINYLIDENE MONOMERS PRODUCED BY FREE RADICAL POLYMERIZATION AMOCO CORPORATION (US) 1999-02-03 EP disclosed
WO-1998037112-A1 COPOLYMERS OF HIGH VINYLIDENE POLYOLEFINS WITH VINYL OR VINYLIDENE MONOMERS PRODUCED BY FREE RADICAL POLYMERIZATION AMOCO CORPORATION (US) 1998-08-27 WO disclosed