Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.48 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9195127 | 1.00 | ACHE (0.49) | ACHECYP4F2CYP4A11DRD2DRD3 | |
| SCHEMBL9191715 | 1.00 | ACHE (0.49) | ACHECYP4F2CYP4A11DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL9133231 | 0.99 | ACHE (0.48) | ACHECYP4F2CYP4A11DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL9133151 | 0.99 | ACHE (0.48) | ACHECYP4F2CYP4A11DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL9133223 | 0.99 | ACHE (0.48) | ACHECYP4F2CYP4A11DRD2DRD3 | |
| SCHEMBL9199191 | 0.93 | ACHE (0.47) | ACHECYP4F2CYP4A11DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL9134280 | 0.92 | ACHE (0.47) | ACHECYP4F2CYP4A11DRD2DRD3 | |
| SCHEMBL3542730 | 0.90 | CYP4F2 (0.52) | CYP4F2CYP4A11DRD2DRD3HRH3 | |
| Hydrochloric Acid SCHEMBL4784560 | 0.89 | CYP4F2 (0.51) | CYP4F2CYP4A11DRD2DRD3HRH3 | |
| SCHEMBL9192369 | 0.86 | CYP4F2 (0.46) | CYP4F2CYP4A11DRD2DRD3HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030160-B2 | Propanolaminotetralines, preparation thereof and compositions containing same | SANOFI-AVENTIS (FR) | 2006-04-18 | — | — | US | disclosed |
| US-20040034070-A1 | Propanolaminotetralines, preparation thereof and compositions containing same | SANOFI-AVENTIS (FR) | 2004-02-19 | — | — | US | disclosed |
| EP-1292572-B1 | PROPANOLAMINOTETRALINES, PREPARATION THEREOF AND COMPOSITIONS CONTAINING SAME | SANOFI SYNTHELABO (FR) | 2004-02-18 | — | — | EP | disclosed |
| EP-1292572-A1 | PROPANOLAMINOTETRALINES, PREPARATION THEREOF AND COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001094307-A1 | PROPANOLAMINOTETRALINES, PREPARATION THEREOF AND COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2001-12-13 | — | — | WO | disclosed |
| EP-0500443-B1 | Phenylethanolamino- and phenylethanolaminomethyltetralines, process for their preparation, intermediates of this process and pharmaceutical compositions containing them | SANOFI SA (FR) | 1995-04-26 | — | — | EP | disclosed |
| EP-0500443-A1 | Phenylethanolamino- and phenylethanolaminomethyltetralines, process for their preparation, intermediates of this process and pharmaceutical compositions containing them | SANOFI (FR) | 1992-08-26 | — | — | EP | disclosed |
| EP-0499755-A1 | Phenylethanolaminotetralines, process for their preparation, intermediates of this process and pharmaceutical compositions containing them | MIDY S.p.A. (IT) | 1992-08-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034070-A1 | Propanolaminotetralines, preparation thereof and compositions containing same | ADRB3, ADRB1, ADRB2 | ACHE 79/4885CYP4F2 1526/4885CYP4A11 143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.