SCHEMBL5679481

SCHEMBL5679481

CS(=O)(=O)[O-].Cc1cc[n+](C)c2ccccc12

nearest known ligand 0.46

Known targets — ChEMBL curated mechanism

ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.46
RCE1 Q9Y256 1/20 0.46
MAPT P10636 4/20 0.45
HTT P42858 3/20 0.45
SMN1; SMN2 Q16637 3/20 0.45
CHAT P28329 1/20 0.41
KDM4E B2RXH2 3/20 0.41
POLB P06746 3/20 0.41
RECQL P46063 2/20 0.40
NPSR1 Q6W5P4 3/20 0.39
RAD52 P43351 2/20 0.39
MAPK1 P28482 2/20 0.39
PKM P14618 1/20 0.39
ALDH1A1 P00352 2/20 0.38
NQO2 P16083 1/20 0.37
MEN1 O00255 2/20 0.37
BLM P54132 2/20 0.37
KMT2A Q03164 2/20 0.37
JAK2 O60674 1/20 0.37
GAA P10253 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6332742 0.89 RAB9A (0.43) RAB9ARCE1MAPTHTTSMN1; SMN2
Trifluoromethanesulfonic Acid SCHEMBL7074404 0.87 RAB9A (0.42) RAB9ARCE1MAPTHTTSMN1; SMN2
SCHEMBL30894444 0.87 MAPT (0.55) RAB9ARCE1MAPTHTTSMN1; SMN2
SCHEMBL1049804 0.87 MAPT (0.55) RAB9ARCE1MAPTHTTSMN1; SMN2
SCHEMBL1002271 0.86 KDM4E (0.42) RAB9ARCE1MAPTHTTSMN1; SMN2
Iodide SCHEMBL336208 0.85 MAPT (0.53) RAB9ARCE1MAPTHTTSMN1; SMN2
Hydrochloric Acid SCHEMBL6330564 0.85 MAPT (0.58) RAB9ARCE1MAPTHTTSMN1; SMN2
Iodide SCHEMBL29462686 0.85 MAPT (0.53) RAB9ARCE1MAPTHTTSMN1; SMN2
SCHEMBL11074520 0.81 HTT (0.48) RAB9ARCE1MAPTHTTSMN1; SMN2
SCHEMBL28731928 0.80 MAPT (0.49) RAB9ARCE1MAPTHTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1200051-B1 AGENT FOR DYING KERATIN FIBERS HENKEL KGAA (DE) 2006-02-01 EP disclosed