Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | CHAT | P28329 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TERT | O14746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11074520 | 0.86 | HTT (0.48) | KDM4EMAPTSMN1; SMN2HTTLMNA | |
| SCHEMBL5679481 | 0.86 | RAB9A (0.46) | KDM4EMAPTSMN1; SMN2HTTRAB9A | |
| SCHEMBL3323373 | 0.86 | LMNA (0.40) | KDM4ESMN1; SMN2HTTLMNARAB9A | |
| SCHEMBL30278762 | 0.83 | CHAT (0.46) | KDM4EMAPTSMN1; SMN2HTTLMNA | |
| SCHEMBL3885913 | 0.83 | CHAT (0.46) | KDM4EMAPTSMN1; SMN2HTTLMNA | |
| SCHEMBL11209473 | 0.83 | LMNA (0.38) | KDM4EMAPTSMN1; SMN2HTTLMNA | |
| SCHEMBL6332742 | 0.82 | RAB9A (0.43) | KDM4EMAPTSMN1; SMN2HTTLMNA | |
| SCHEMBL1838460 | 0.82 | KDM4E (0.61) | KDM4EMAPTHSD17B10SMN1; SMN2HTT | |
| Trifluoromethanesulfonic Acid SCHEMBL7074404 | 0.81 | RAB9A (0.42) | KDM4EMAPTSMN1; SMN2HTTRAB9A | |
| SCHEMBL30894444 | 0.80 | MAPT (0.55) | KDM4EMAPTSMN1; SMN2HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362579-B1 | Agent for dyeing keratinous fibres | HENKEL KGAA (DE) | 2006-05-24 | — | — | EP | claimed |
| EP-1300135-B1 | Agent for dyeing keratinous fibres comprising 2-aryliden-indolin-3-one derivatives | HENKEL KGAA (DE) | 2006-05-03 | — | — | EP | claimed |
| EP-1433785-A1 | Agents for the coloration of keratinous fibres | Henkel Kommanditgesellschaft auf Aktien (DE) | 2004-06-30 | — | — | EP | claimed |
| EP-1362579-A1 | Agent for dyeing keratinous fibres | Henkel Kommanditgesellschaft auf Aktien (DE) | 2003-11-19 | — | — | EP | claimed |
| EP-1300132-A2 | Agent for dyeing keratinous fibres | Henkel Kommanditgesellschaft auf Aktien (DE) | 2003-04-09 | — | — | EP | claimed |
| EP-1300135-A1 | Agent for dyeing keratinous fibres | Henkel Kommanditgesellschaft auf Aktien (DE) | 2003-04-09 | — | — | EP | claimed |
| US-10011570-B2 | Nucleic acid binding dyes with improved safety | BIOTIUM, INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-10005908-B2 | Methine-substituted cyanine dye compounds | Life Technologies Corporation (US) | 2018-06-26 | — | — | US | disclosed |
| US-20160304719-A1 | Methine-Substituted Cyanine Dye Compounds | Life Technologies Corporation | 2016-10-20 | — | — | US | disclosed |
| EP-2610315-B1 | Methine-substituted cyanine dye compounds | LIFE TECHNOLOGIES CORP (US) | 2016-08-31 | — | — | EP | disclosed |
| US-9403985-B2 | Methine-substituted cyanine dye compounds | Life Technologies Corporation (US) | 2016-08-02 | — | — | US | disclosed |
| US-9382425-B2 | Aza-benzazolium containing cyanine dyes | Life Technologies Corporation (US) | 2016-07-05 | — | — | US | disclosed |
| EP-1720945-B1 | METHINE-SUBSTITUTED CYANINE DYE COMPOUNDS | LIFE TECHNOLOGIES CORP (US) | 2016-03-16 | — | — | EP | disclosed |
| WO-2000066664-A1 | AZA-BENZAZOLIUM CONTAINING CYANINE DYES | MOLECULAR PROBES, INC. (US) | 2000-11-09 | — | — | WO | disclosed |
| US-5676884-A | Nonlinear optical materials containing polar disulfone-functionalized molecules | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1997-10-14 | — | — | US | disclosed |
| US-5578251-A | NONLINEAR-OPTICAL RESPONSE; ALKYLATION | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| US-5360582-A | Compositions with polymers for light sensitive elements | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1994-11-01 | — | — | US | disclosed |
| EP-0594697-A1 | NONLINEAR OPTICAL MATERIALS CONTAINING POLAR DISULFONE-FUNCTIONALIZED MOLECULES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1994-05-04 | — | — | EP | disclosed |
| WO-1993002383-A1 | NONLINEAR OPTICAL MATERIALS CONTAINING POLAR DISULFONE-FUNCTIONALIZED MOLECULES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1993-02-04 | — | — | WO | disclosed |
| US-3944556-A | PHOTOCONDUCTOR, FLUORESCENT, PHOTOGRAPHY | FUJI PHOTO FILM CO., LTD. (JA) | 1976-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10011570-B2 | Nucleic acid binding dyes with improved safety | POLRMT, POLI, EWSR1 | KDM4E 3940/4885MAPT 2181/4885HSD17B10 2702/4885 |
| US-10005908-B2 | Methine-substituted cyanine dye compounds | NSUN2, NSUN3, CBR3 | KDM4E 1203/4885MAPT 4546/4885HSD17B10 3393/4885 |
| US-20160304719-A1 | Methine-Substituted Cyanine Dye Compounds | NSUN2, NSUN3, CBR3 | KDM4E 1203/4885MAPT 4546/4885HSD17B10 3393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.