Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | FDPS | P14324 | 10/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GGPS1 | O95749 | 6/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.37 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17241830 | 1.00 | TSHR (0.44) | TSHRTHRBFDPSSMPD1ALDH1A1 | |
| SCHEMBL1639544 | 0.88 | TSHR (0.50) | TSHRTHRBFDPSSMPD1ALDH1A1 | |
| SCHEMBL3346971 | 0.88 | TSHR (0.50) | TSHRTHRBFDPSSMPD1ALDH1A1 | |
| SCHEMBL27778757 | 0.86 | TSHR (0.47) | TSHRTHRBFDPSSMPD1ALDH1A1 | |
| Methylene Chloride SCHEMBL3865938 | 0.83 | TSHR (0.48) | TSHRTHRBFDPSSMPD1ALDH1A1 | |
| Methylene Chloride SCHEMBL2064725 | 0.83 | TSHR (0.48) | TSHRTHRBFDPSSMPD1ALDH1A1 | |
| Methylene Chloride SCHEMBL19064598 | 0.83 | TSHR (0.48) | TSHRTHRBFDPSSMPD1ALDH1A1 | |
| Methylene Chloride SCHEMBL2388456 | 0.83 | TSHR (0.48) | TSHRTHRBFDPSSMPD1ALDH1A1 | |
| SCHEMBL10839732 | 0.82 | TSHR (0.41) | TSHRTHRBFDPSSMPD1ALDH1A1 | |
| SCHEMBL8197016 | 0.80 | FDPS (0.39) | TSHRTHRBFDPSSMPD1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626046-B1 | Photochromic oxazine compounds and methods for their manufacture | ESSILOR INT (FR) | 2014-11-19 | — | — | EP | disclosed |
| EP-1458695-B1 | Method for the manufacture of photochromic oxazine compounds and compounds obtainable therefrom | ESSILOR INT (FR) | 2012-10-03 | — | — | EP | disclosed |
| CN-1305861-C | Photochromic oxazine compounds and methods for their manufacture | JOHNSON & JOHNSON VISION CARE (FR) | 2007-03-21 | — | — | CN | disclosed |
| EP-1626046-A1 | Photochromic oxazine compounds and methods for their manufacture | Johson & Johnson Vision Care Inc. (US) | 2006-02-15 | — | — | EP | disclosed |
| CN-1617861-A | Photochromic oxazine compounds and methods for their manufacture | JOHNSON & JOHNSON VISION CARE (US) | 2005-05-18 | — | — | CN | disclosed |
| EP-1458695-A1 | PHOTOCHROMIC OXAZINE COMPOUNDS AND METHODS FOR THEIR MANUFACTURE | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2004-09-22 | — | — | EP | disclosed |
| US-6720420-B2 | AROMATIC, HETEROAROMATIC, OR ALIPHATIC SUBSTITUENTS AT THE 2 POSITION OF THE OXAZINE MOIETY; REACTING 3,3-DISUBSTITUTED ACRYLIC ACID, AZIDE SOURCE, QUINONE WITH CATALYTIC TRIPHENYLARSENIC OXIDE AND DBU; QUICKLY FADING GRAY COLOR | JOHNSON & JOHNSON VISION CARE, INC. | 2004-04-13 | — | — | US | disclosed |
| WO-2003057679-A9 | PHOTOCHROMIC OXAZINE COMPOUNDS AND METHODS FOR THEIR MANUFACTURE | JOHNSON & JOHNSON VISION CARE (US) | 2004-02-26 | — | — | WO | disclosed |
| US-20030149032-A1 | Photochromic oxazine compounds and methods for their manufacture | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2003-08-07 | — | — | US | disclosed |
| WO-2003057679-A1 | PHOTOCHROMIC OXAZINE COMPOUNDS AND METHODS FOR THEIR MANUFACTURE | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2003-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149032-A1 | Photochromic oxazine compounds and methods for their manufacture | PPOX, TYR, DHPS | TSHR 3755/4885THRB 4345/4885FDPS 606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.