Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 6/20 | 0.37 |
| ▸ | HTR2C known ✓ | P28335 | 6/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.34 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5682166 | 1.00 | HTR2A (0.37) | HTR2AHTR2CNPSR1LMNAPMP22 | |
| Fumaric Acid SCHEMBL5682016 | 0.91 | HTR2A (0.41) | HTR2AHTR2CNPSR1LMNAPMP22 | |
| Fumaric Acid SCHEMBL5682001 | 0.91 | HTR2A (0.41) | HTR2AHTR2CNPSR1LMNAPMP22 | |
| SCHEMBL905693 | 0.88 | ADORA2A (0.45) | HTR2AHTR2CADORA2AADORA2B | |
| Fumaric Acid SCHEMBL4845606 | 0.82 | HTR2A (0.47) | HTR2AHTR2CNPSR1LMNAPMP22 | |
| Fumaric Acid SCHEMBL4845619 | 0.82 | HTR2A (0.47) | HTR2AHTR2CNPSR1LMNAPMP22 | |
| Fumaric Acid SCHEMBL5678010 | 0.80 | GLS (0.46) | HTR2AHTR2CNPSR1LMNAPMP22 | |
| Fumaric Acid SCHEMBL5678017 | 0.80 | GLS (0.46) | HTR2AHTR2CNPSR1LMNAPMP22 | |
| Fumaric Acid SCHEMBL5682174 | 0.80 | ADORA2A (0.56) | ADORA2AADORA2BKMOSLC22A12 | |
| Fumaric Acid SCHEMBL6364123 | 0.79 | HTR2C (0.48) | HTR2AHTR2CKMOSLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129078-B1 | INDAZOLE DERIVATIVES WITH 5-HT2 RECEPTOR ACTIVITY | VERNALIS RES LTD (GB) | 2006-03-15 | — | — | EP | disclosed |
| US-6552062-B1 | For therapy of central nervous system disorders; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus, and sleep apnea, and obesity | VERNALIS RESEARCH LIMITED (GB) | 2003-04-22 | — | — | US | disclosed |