SCHEMBL5683259

SCHEMBL5683259

COC(=O)c1ccc2c(c1)c(C1=C(c3cn(CCCO)c4ccccc34)C(=O)NC1=O)cn2C

nearest known ligand 0.80

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 2/20 0.61
KDR P35968 1/20 0.61
FLT3 P36888 1/20 0.61
PIM1 P11309 2/20 0.60
CAMK2D Q13557 1/20 0.60
PRKCA P17252 2/20 0.58
PRKACA P17612 2/20 0.58
PRKACG P22612 2/20 0.58
PRKACB P22694 2/20 0.58
PRKCB P05771 1/20 0.56
PRKCE Q02156 1/20 0.56
CDK4 P11802 1/20 0.56
CCND1 P24385 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30319768 1.00 GSK3B (0.61) GSK3BKDRFLT3PIM1CAMK2D
SCHEMBL14555040 0.89 CCNE2 (0.66) GSK3BPRKCACDK4CCND1
SCHEMBL3139598 0.86 GSK3B (0.78) GSK3BPIM1CAMK2DPRKCAPRKACA
SCHEMBL14041601 0.86 GSK3B (0.66) GSK3BKDRFLT3PIM1CAMK2D
SCHEMBL6950855 0.83 CCNE2 (0.66) GSK3BKDRPRKCACDK4CCND1
SCHEMBL3150613 0.83 PIM1 (0.77) GSK3BPIM1CAMK2DPRKCAPRKACA
SCHEMBL5686033 0.83 GSK3B (0.66) GSK3BKDRFLT3PIM1CAMK2D
SCHEMBL8166369 0.82 PIM1 (0.75) GSK3BPIM1CAMK2DPRKCAPRKACA
SCHEMBL7873644 0.81 PRKACA (0.80) GSK3BKDRFLT3PIM1CAMK2D
SCHEMBL5682666 0.81 GSK3B (0.62) GSK3BPIM1CAMK2DPRKCAPRKACA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200206188-A1 COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGS THEREOF, INCLUDING MEISOINDIGO BROWN DENNIS M (US) 2020-07-02 US claimed
US-20160243077-A1 COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGS THEREOF, INCLUDING MEISOINDIGO BROWN DENNIS M (US) 2016-08-25 US claimed
US-20150087687-A1 COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGS THEREOF, INCLUDING MEISOINDIGO BROWN DENNIS (US) 2015-03-26 US claimed
EP-2827869-A2 COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGS THEREOF, INCLUDING MEISOINDIGO Brown, Dennis (US) 2015-01-28 EP claimed
WO-2013142817-A2 COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGS THEREOF, INCLUDING MEISOINDIGO BROWN DENNIS (US) 2013-09-26 WO claimed
US-20060217368-A1 Drug for nerve regeneration KYOWA HAKKO KOGYO CO., LTD. (JP) 2006-09-28 US claimed
EP-1645286-A1 DRUG FOR NERVE REGENERATION KYOWA HAKKO KOGYO CO., LTD. (JP) 2006-04-12 EP claimed
EP-1140070-A1 TREATMENT OF CONDITIONS WITH A NEED FOR THE INHIBITION OF GSK-3 SMITHKLINE BEECHAM PLC (GB) 2001-10-10 EP claimed
WO-2000038675-A1 TREATMENT OF CONDITIONS WITH A NEED FOR THE INHIBITION OF GSK-3 SMITHKLINE BEECHAM PLC (GB) 2000-07-06 WO claimed
US-20230100193-A1 NOVEL PHARMACEUTICAL FORMULATIONS CONTAINING INDIRUBIN AND DERIVATIVES THEREOF AND METHODS OF MAKING AND USING THE SAME CYTODIGM, INC. 2023-03-30 US disclosed
US-20200383931-A1 NOVEL PHARMACEUTICAL FORMULATIONS CONTAINING INDIRUBIN AND DERIVATIVES THEREOF AND METHODS OF MAKING AND USING THE SAME CYTODIGM, INC. 2020-12-10 US disclosed
US-20200206188-A1 COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGS THEREOF, INCLUDING MEISOINDIGO BROWN DENNIS M (US) 2020-07-02 US disclosed
EP-3600259-A1 NOVEL PHARMACEUTICAL FORMULATIONS CONTAINING INDIRUBIN AND DERIVATIVES THEREOF AND METHODS OF MAKING AND USING THE SAME Phosphorex, Inc. (US) 2020-02-05 EP disclosed
CN-110709066-A Novel pharmaceutical formulations containing indirubin and derivatives thereof and methods of making and using the same 法斯瑞斯公司 2020-01-17 CN disclosed
WO-2005028678-A9 METHODS AND MATERIALS FOR IDENTIFYING AGENTS WHICH MODULATE BONE REMODELING AND AGENTS IDENTIFIED THEREBY WYETH CORP (US) 2006-08-31 WO disclosed
EP-1645286-A1 DRUG FOR NERVE REGENERATION KYOWA HAKKO KOGYO CO., LTD. (JP) 2006-04-12 EP disclosed
EP-1636388-A2 METHODS AND MATERIALS FOR IDENTIFYING AGENTS WHICH MODULATE BONE REMODELING AND AGENTS IDENTIFIED THEREBY Wyeth (US) 2006-03-22 EP disclosed
WO-2005028678-A2 METHODS AND MATERIALS FOR IDENTIFYING AGENTS WHICH MODULATE BONE REMODELING AND AGENTS IDENTIFIED THEREBY WYETH (US) 2005-03-31 WO disclosed
EP-1140070-A1 TREATMENT OF CONDITIONS WITH A NEED FOR THE INHIBITION OF GSK-3 SMITHKLINE BEECHAM PLC (GB) 2001-10-10 EP disclosed
WO-2000038675-A1 TREATMENT OF CONDITIONS WITH A NEED FOR THE INHIBITION OF GSK-3 SMITHKLINE BEECHAM PLC (GB) 2000-07-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230100193-A1 NOVEL PHARMACEUTICAL FORMULATIONS CONTAINING INDIRUBIN AND DERIVATIVES THEREOF AND METHODS OF MAKING AND USING THE SAME UGT2B7, UGT1A7, CYP3A7 GSK3B 387/4885KDR 3334/4885FLT3 1926/4885
US-20060217368-A1 Drug for nerve regeneration GSK3A, BDNF, GSK3B GSK3B 3/4885KDR 1689/4885FLT3 2100/4885
US-20200383931-A1 NOVEL PHARMACEUTICAL FORMULATIONS CONTAINING INDIRUBIN AND DERIVATIVES THEREOF AND METHODS OF MAKING AND USING THE SAME UGT2B7, UGT1A7, CYP3A7 GSK3B 387/4885KDR 3334/4885FLT3 1926/4885
US-20200206188-A1 COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGS THEREOF, INCLUDING MEISOINDIGO NEK9, NEK7, NEK3 GSK3B 37/4885KDR 4228/4885FLT3 3630/4885
US-20150087687-A1 COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGS THEREOF, INCLUDING MEISOINDIGO CYP7A1, CYP3A7, UGT2B7 GSK3B 222/4885KDR 3908/4885FLT3 1413/4885
US-20160243077-A1 COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGS THEREOF, INCLUDING MEISOINDIGO NEK9, NEK7, NEK3 GSK3B 37/4885KDR 4228/4885FLT3 3630/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.