Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5683622 | 0.96 | TGFBR1 (0.45) | KDM4ETGFBR1ACVR1TP53MEN1 | |
| SCHEMBL5682153 | 0.82 | TP53 (0.49) | KDM4EPOLBTGFBR1ACVR1TP53 | |
| SCHEMBL4763891 | 0.79 | KDM4E (0.53) | KDM4EPOLBTGFBR1ACVR1MEN1 | |
| SCHEMBL5681214 | 0.78 | TP53 (0.52) | KDM4EPOLBTGFBR1ACVR1TP53 | |
| SCHEMBL7159444 | 0.77 | DRD4 (0.49) | KDM4EHCRTR1HCRTR2SLC29A1CXCR4 | |
| SCHEMBL12962167 | 0.77 | DRD4 (0.62) | KDM4ETDP1HCRTR1HCRTR2ACKR3 | |
| SCHEMBL2765186 | 0.77 | HTR7 (0.57) | KDM4EALDH1A1TDP1ACKR3 | |
| SCHEMBL5679807 | 0.77 | KDM4E (0.61) | KDM4EPOLBTGFBR1ACVR1MEN1 | |
| SCHEMBL5681143 | 0.76 | SYK (0.47) | KDM4EALDH1A1GAKSYK | |
| SCHEMBL5679879 | 0.76 | SYK (0.47) | KDM4EALDH1A1TDP1GAKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1403249-B1 | CYCLIC DIAMINE COMPOUNDS BEARING SIX-MEMBERED CYCLIC GROUPS | KOWA CO (JP) | 2006-03-15 | — | — | EP | disclosed |
| EP-1403249-A1 | CYCLIC DIAMINE COMPOUNDS BEARING SIX-MEMBERED CYCLIC GROUPS | Kowa Co., Ltd. (JP) | 2004-03-31 | — | — | EP | disclosed |
| US-6509329-B1 | Inhibitory effects on both cell adhesion and cell infiltration and is useful as a medicine for prevention or treatment of diseases such as allergy, asthma, rheumatism, arteriosclerosis and inflammation | KOWA CO., LTD. (JP) | 2003-01-21 | — | — | US | disclosed |