Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | SLC29A1 | Q99808 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5681214 | 0.96 | TP53 (0.52) | TP53GAAKDM4EPOLBTGFBR1 | |
| SCHEMBL5683281 | 0.82 | KDM4E (0.48) | TP53GAAKDM4EPOLBTGFBR1 | |
| SCHEMBL5683622 | 0.78 | TGFBR1 (0.45) | TP53GAAKDM4ETGFBR1ACVR1 | |
| SCHEMBL5679867 | 0.78 | FYN (0.44) | CYP3A4CYP2D6CYP2C9TSHRCYP2C19 | |
| SCHEMBL5683223 | 0.78 | MAPT (0.42) | KDM4EMEN1KMT2ASMN1; SMN2CYP3A4 | |
| SCHEMBL4763891 | 0.77 | KDM4E (0.53) | KDM4EPOLBTGFBR1ACVR1SLC29A1 | |
| SCHEMBL2765186 | 0.75 | HTR7 (0.57) | KDM4EKCNH2HTR7ALDH1A1TDP1 | |
| SCHEMBL5679677 | 0.74 | TP53 (0.47) | TP53GAAKDM4ETGFBR1ACVR1 | |
| SCHEMBL2764403 | 0.74 | DRD2 (0.49) | TP53GAAKDM4EPOLBMEN1 | |
| SCHEMBL2911110 | 0.73 | KDM4E (0.46) | KDM4EPOLBTGFBR1ACVR1SLC29A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1403249-B1 | CYCLIC DIAMINE COMPOUNDS BEARING SIX-MEMBERED CYCLIC GROUPS | KOWA CO (JP) | 2006-03-15 | — | — | EP | disclosed |
| EP-1403249-A1 | CYCLIC DIAMINE COMPOUNDS BEARING SIX-MEMBERED CYCLIC GROUPS | Kowa Co., Ltd. (JP) | 2004-03-31 | — | — | EP | disclosed |
| US-6509329-B1 | Inhibitory effects on both cell adhesion and cell infiltration and is useful as a medicine for prevention or treatment of diseases such as allergy, asthma, rheumatism, arteriosclerosis and inflammation | KOWA CO., LTD. (JP) | 2003-01-21 | — | — | US | disclosed |