Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | FABP4 | P15090 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | RPA1 | P27694 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | FABP3 | P05413 | 1/20 | 0.37 |
| ▸ | MYC | P01106 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4142033 | 0.85 | CASP1 (0.49) | CASP1FABP4ALDH1A1CYP3A4KDM4E | |
| SCHEMBL7366744 | 0.84 | L3MBTL1 (0.41) | CASP1ALDH1A1CA1CA2CA5A | |
| SCHEMBL4759798 | 0.83 | CASP1 (0.48) | CASP1FABP4CYP3A4CYP2C9CA12 | |
| SCHEMBL30950298 | 0.78 | ALDH1A1 (0.44) | ALDH1A1HSD17B10TDP1KDM4EPOLB | |
| SCHEMBL4439 | 0.78 | ALDH1A1 (0.44) | ALDH1A1HSD17B10TDP1KDM4EPOLB | |
| SCHEMBL12097036 | 0.77 | CASP1 (0.44) | CASP1FABP4TDP1CYP3A4KDM4E | |
| Water SCHEMBL9476427 | 0.76 | ALDH1A1 (0.42) | ALDH1A1HSD17B10TDP1KDM4EPOLB | |
| SCHEMBL1584604 | 0.76 | ALDH1A1 (0.48) | ALDH1A1HSD17B10TDP1KDM4EPOLB | |
| SCHEMBL1109716 | 0.76 | ALDH1A1 (0.42) | ALDH1A1HSD17B10TDP1KDM4EPOLB | |
| SCHEMBL1584603 | 0.76 | ALDH1A1 (0.42) | ALDH1A1HSD17B10TDP1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0932600-B1 | SULFONAMIDE SUBSTITUTED ASPARTIC ACID INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITORS | WARNER LAMBERT CO (US) | 2006-02-08 | — | — | EP | disclosed |
| US-6083981-A | USEFUL FOR TREATMENT OF STROKE, INFLAMMATORY DISEASES, SEPTIC SHOCK, REPERFUSION INJURY, ALZHEIMER'S DISEASE, SHIGELLOSIS | WARNER-LAMBERT COMPANY (US) | 2000-07-04 | — | — | US | disclosed |
| US-6054487-A | ADMINISTERING AN INTERLEUKIN-ONE BETA CONVERTING ENZYME SUFFICIENT TO INHIBIT PRODUCTION OF GAMMA-INTERFERON | BASF AKTIENGESELLSCHAFT (DE) | 2000-04-25 | — | — | US | disclosed |