Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.60 |
| ▸ | BRD2 | P25440 | 4/20 | 0.60 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.54 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.45 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5686141 | 1.00 | BRD4 (0.60) | BRD4BRD2BRD3BRDTHSD11B1 | |
| SCHEMBL5717368 | 0.83 | BRD4 (0.56) | BRD4BRD2BRD3BRDTHSD11B1 | |
| SCHEMBL5717132 | 0.83 | PSEN1 (0.70) | BRD4BRD2BRD3BRDTHSD11B1 | |
| SCHEMBL8051860 | 0.80 | RAB9A (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8069484 | 0.80 | PSEN1 (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5129006 | 0.80 | BRD4 (0.56) | BRD4BRD2BRD3BRDTHSD11B1 | |
| SCHEMBL4539776 | 0.79 | BRD4 (0.53) | BRD4BRD2BRD3BRDTBDKRB1 | |
| SCHEMBL5716989 | 0.79 | ALDH1A1 (0.66) | BRD4BRD2BRD3BRDTHSD11B1 | |
| SCHEMBL5716988 | 0.79 | ALDH1A1 (0.66) | BRD4BRD2BRD3BRDTHSD11B1 | |
| SCHEMBL5717022 | 0.79 | ALDH1A1 (0.66) | BRD4BRD2BRD3BRDTHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |
| EP-1633743-A1 | CYCLIC AMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF INFLAMMATION-RELATED DISORDERS MEDIATED BY BRADYKININ | Amgen, Inc. (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004092164-A1 | CYCLIC AMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF INFLAMMATION-RELATED DISORDERS MEDIATED BY BRADYKININ | AMGEN, INC. (US) | 2004-10-28 | — | — | WO | disclosed |