Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 3/20 | 0.62 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.62 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.62 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.62 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.62 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8051860 | 0.87 | RAB9A (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8051885 | 0.82 | BDKRB1 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9893067 | 0.81 | PSEN1 (0.92) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5686141 | 0.80 | BRD4 (0.60) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5686148 | 0.80 | BRD4 (0.60) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5250378 | 0.80 | PSEN1 (0.75) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5915289 | 0.78 | PSEN1 (0.69) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8064639 | 0.78 | KDM4E (0.50) | USP2ALDH1A1HPGDTSHRLMNA | |
| SCHEMBL8060028 | 0.78 | HTR7 (0.61) | HTR7CYP3A4 | |
| SCHEMBL4542928 | 0.77 | LMNA (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |