SCHEMBL5688397

SCHEMBL5688397

C=CCOC(=O)Cc1ccc(OC2CCN(C(=O)Oc3ccc(Oc4ccc(Cl)cn4)cc3)CC2)cc1

nearest known ligand 0.43

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
LIPE Q05469 12/20 0.43
BCHE P06276 1/20 0.39
EGFR P00533 2/20 0.39
BTK Q06187 2/20 0.39
GPR119 Q8TDV5 1/20 0.37
ALDH1A1 P00352 1/20 0.36
ACACB O00763 1/20 0.36
HRH3 Q9Y5N1 1/20 0.36
EGLN1 Q9GZT9 1/20 0.36
FAAH O00519 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5688171 0.88 LIPE (0.60) LIPEBCHE
SCHEMBL5687339 0.86 LIPE (0.49) LIPEBCHEGPR119ACACBHRH3
SCHEMBL5688106 0.83 CHRNA7 (0.42) ALDH1A1
SCHEMBL5688793 0.82 F10 (0.40) ALDH1A1
SCHEMBL5687869 0.81 LMNA (0.53) LIPEBCHEALDH1A1FAAH
SCHEMBL5688053 0.81 F2 (0.39)
SCHEMBL5687896 0.80 LIPE (0.58) LIPEBCHEFAAH
SCHEMBL5689876 0.80 LIPE (0.51) LIPEBCHEGPR119HRH3
SCHEMBL5687680 0.80 LIPE (0.52) LIPEBCHEGPR119HRH3
SCHEMBL5688139 0.79 LIPE (0.61) LIPEBCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060160851-A1 Substituted piperidine carbamates NOVO NORDISK A/S (DK) 2006-07-20 US disclosed
EP-1636207-A1 SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2006-03-22 EP disclosed
WO-2004111032-A1 SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2004-12-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060160851-A1 Substituted piperidine carbamates LIPE, PNLIP, LIPC LIPE 1/4885BCHE 32/4885EGFR 4408/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.