SCHEMBL5688692

SCHEMBL5688692

CNC(=O)c1ccc(OC)c(-c2ccc(C(O)(c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)C(C)C)cc2)c1

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 3/20 0.40
CYP3A4 P08684 3/20 0.40
CTSA P10619 1/20 0.37
BRD4 O60885 1/20 0.36
JAK2 O60674 1/20 0.36
JAK3 P52333 1/20 0.36
SIRT2 Q8IXJ6 5/20 0.36
CASR P41180 2/20 0.35
ACSS2 Q9NR19 2/20 0.35
MAPK14 Q16539 1/20 0.35
SYK P43405 1/20 0.35
AURKB Q96GD4 1/20 0.35
INCENP Q9NQS7 1/20 0.35
HTR2C P28335 1/20 0.35
MCHR1 Q99705 1/20 0.35
HPSE Q9Y251 1/20 0.34
POLB P06746 1/20 0.34
MAPT P10636 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5690923 0.88 CYP17A1 (0.41) CYP17A1CYP3A4SIRT2ACSS2
SCHEMBL5691077 0.86 CYP17A1 (0.39) CYP17A1CYP3A4BRD4SIRT2CASR
SCHEMBL5688583 0.84 CYP17A1 (0.56) CYP17A1CYP3A4SIRT2
SCHEMBL5688704 0.83 CYP17A1 (0.44) CYP17A1CYP3A4SIRT2ACSS2
SCHEMBL4031099 0.82 CYP17A1 (0.52) CYP17A1CYP3A4SIRT2ACSS2
SCHEMBL5689096 0.81 CYP17A1 (0.50) CYP17A1CYP3A4SIRT2
SCHEMBL5688555 0.81 CYP17A1 (0.48) CYP17A1CYP3A4
SCHEMBL5688570 0.81 CYP17A1 (0.48) CYP17A1CYP3A4SIRT2ACSS2
SCHEMBL4027190 0.80 CYP3A4 (0.38) CYP17A1CYP3A4SIRT2
SCHEMBL5691363 0.78 CYP3A4 (0.46) CYP17A1CYP3A4SIRT2ACSS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1227086-B1 1-SUBSTITUTED PHENYL-1-(1H-IMIDAZOL-4-YL) ALCOHOLS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF TAKEDA PHARMACEUTICAL (JP) 2006-03-29 EP disclosed
US-6518257-B1 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2003-02-11 US disclosed
EP-1227086-A1 1-SUBSTITUTED PHENYL-1-(1H-IMIDAZOL-4-YL) ALCOHOLS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF Takeda Chemical Industries, Ltd. (JP) 2002-07-31 EP disclosed