SCHEMBL5690408

SCHEMBL5690408

O=C(Oc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1)N1CCC(Sc2ccncc2)CC1

nearest known ligand 0.71

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
LIPE Q05469 15/20 0.71
BCHE P06276 1/20 0.66
SCN9A Q15858 3/20 0.47
CYP3A4 P08684 1/20 0.46
GAA P10253 1/20 0.46
MAPT P10636 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
HTT P42858 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
MGLL Q99685 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5687908 0.85 LIPE (0.68) LIPEBCHECYP3A4GAAMAPT
SCHEMBL5687271 0.85 LIPE (0.60) LIPEBCHESCN9AMGLL
SCHEMBL5689150 0.85 LIPE (0.70) LIPEBCHESCN9A
SCHEMBL5931777 0.84 LIPE (0.69) LIPEBCHESCN9ACYP3A4GAA
SCHEMBL5688258 0.84 LIPE (0.59) LIPEBCHESCN9A
SCHEMBL5689143 0.84 LIPE (0.68) LIPEBCHESCN9AMAPTHTT
SCHEMBL5689964 0.83 LIPE (0.67) LIPEBCHESCN9AMAPTHTT
SCHEMBL5649993 0.83 LIPE (1.00) LIPEBCHESCN9ACYP3A4GAA
SCHEMBL5688646 0.83 LIPE (0.73) LIPEBCHESCN9ACYP3A4GAA
SCHEMBL5646858 0.82 LIPE (1.00) LIPEBCHESCN9ACYP3A4GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060160851-A1 Substituted piperidine carbamates NOVO NORDISK A/S (DK) 2006-07-20 US claimed
EP-1636207-A1 SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2006-03-22 EP claimed
WO-2004111032-A1 SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2004-12-23 WO claimed
US-20060160851-A1 Substituted piperidine carbamates NOVO NORDISK A/S (DK) 2006-07-20 US disclosed
EP-1636207-A1 SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2006-03-22 EP disclosed
WO-2004111032-A1 SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2004-12-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060160851-A1 Substituted piperidine carbamates LIPE, PNLIP, LIPC LIPE 1/4885BCHE 32/4885SCN9A 1827/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.