Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 11/20 | 0.74 |
| ▸ | RXRG | P48443 | 11/20 | 0.74 |
| ▸ | RXRB | P28702 | 10/20 | 0.74 |
| ▸ | BACE1 | P56817 | 1/20 | 0.62 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.62 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.56 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.56 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.56 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.56 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.56 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.56 |
| ▸ | MME | P08473 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23296145 | 0.89 | RXRA (0.58) | RXRARXRGRXRBBACE1SLC13A5 | |
| SCHEMBL3836182 | 0.88 | RXRA (0.60) | RXRARXRGRXRBBACE1SLC13A5 | |
| SCHEMBL8337601 | 0.85 | SLC13A5 (0.67) | RXRARXRGRXRBBACE1SLC13A5 | |
| SCHEMBL6267349 | 0.84 | PSEN1 (0.64) | RXRARXRGRXRBABCC4LMNA | |
| SCHEMBL2272003 | 0.83 | RXRA (0.77) | RXRARXRGRXRBABCC4LMNA | |
| SCHEMBL18427881 | 0.83 | ABCC4 (0.80) | RXRARXRGRXRBABCC4LMNA | |
| SCHEMBL5692025 | 0.82 | BACE1 (0.60) | RXRARXRGRXRBBACE1SLC13A5 | |
| Phenylacetic Acid SCHEMBL1807174 | 0.82 | MEN1 (0.66) | RXRARXRGRXRBHTTPSEN1 | |
| SCHEMBL29935522 | 0.82 | MEN1 (0.65) | RXRARXRGRXRBHTTPSEN1 | |
| SCHEMBL378581 | 0.82 | MEN1 (0.65) | RXRARXRGRXRBHTTPSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1657232-A1 | Use of S-enantiomers of alpha-sustituted aryl acetic acids for the prevention of Alzheimer's disease | CELLZOME AG (DE) | 2006-05-17 | — | — | EP | disclosed |
| WO-2006048219-A1 | USE OF S-ENANTIOMERS OF ALPHA-SUBSTITUTED ARYL ACETIC ACIDS FOR THE PREVENTION OF ALZHEIMER’S DISEASE | CELLZOME AG (DE) | 2006-05-11 | — | — | WO | disclosed |
| WO-2006021441-A1 | BIPHENYL-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF AND THEIR USE IN THERAPY | CELLZOME AG (DE) | 2006-03-02 | — | — | WO | disclosed |
| WO-2006021441-A1 | BIPHENYL-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF AND THEIR USE IN THERAPY | CELLZOME AG (DE) | 2006-03-02 | — | — | WO | disclosed |