Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 14/20 | 0.37 |
| ▸ | PGR | P06401 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3058229 | 0.81 | ALDH1A1 (0.45) | ALDH1A1 | |
| SCHEMBL1408112 | 0.78 | ALDH1A1 (0.46) | PIK3CDPIK3R1PIK3CAPIK3CBALDH1A1 | |
| SCHEMBL3059882 | 0.78 | AR (0.49) | ARPGR | |
| SCHEMBL1408560 | 0.73 | ALDH1A1 (0.48) | PIK3CDPIK3R1PIK3CBALDH1A1 | |
| SCHEMBL5693125 | 0.73 | CYP3A4 (0.43) | ARPGR | |
| SCHEMBL5692286 | 0.72 | VCAM1 (0.38) | PGRPIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL2853583 | 0.72 | VCAM1 (0.54) | PTGESARALDH1A1 | |
| SCHEMBL3050476 | 0.71 | AR (0.51) | ARPGR | |
| SCHEMBL5692157 | 0.71 | MAPT (0.41) | ARPGRALDH1A1 | |
| SCHEMBL3045088 | 0.69 | AR (0.51) | ARPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654221-A2 | ANILINE DERIVATIVED ANDROGEN-, GLUCOCORTICOID-, MINERALCORTICOID- AND PROGESTERONE- RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005000795-A2 | ANILINE DERIVATIVED ANDROGEN-, GLUCOCORTICOID-, MINERALCORTICOID- AND PROGESTERONE- RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-06 | — | — | WO | disclosed |