SCHEMBL5692157

SCHEMBL5692157

CCCCN(CC)c1ccc([N+](=O)[O-])c(C(F)(F)F)c1.COCCN(C)c1ccc([N+](=O)[O-])cc1Cl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.41
CYP3A4 P08684 3/20 0.41
MAPK1 P28482 1/20 0.41
HTT P42858 2/20 0.35
TP53 P04637 2/20 0.35
LMNA P02545 4/20 0.35
ALDH1A1 P00352 3/20 0.34
CYP19A1 P11511 3/20 0.34
VCAM1 P19320 2/20 0.34
KMT2A Q03164 3/20 0.33
CRHR1 P34998 1/20 0.33
SMN1; SMN2 Q16637 4/20 0.32
RAB9A P51151 3/20 0.32
NPC1 O15118 2/20 0.32
CYP1A2 P05177 2/20 0.32
CYP2D6 P10635 2/20 0.32
CYP2C9 P11712 2/20 0.32
HPGD P15428 2/20 0.32
CYP2C19 P33261 2/20 0.32
NPSR1 Q6W5P4 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5692492 0.87 MAPT (0.42) MAPTCYP3A4MAPK1HTTTP53
SCHEMBL3054200 0.80 CYP3A4 (0.61) MAPTCYP3A4MAPK1HTTTP53
SCHEMBL3051216 0.78 ALDH1A1 (0.47) MAPTCYP3A4MAPK1HTTTP53
SCHEMBL3058229 0.75 ALDH1A1 (0.45) MAPTMAPK1HTTTP53LMNA
SCHEMBL3047176 0.75 CYP3A4 (0.56) MAPTCYP3A4MAPK1HTTTP53
SCHEMBL3055385 0.75 CYP3A4 (0.49) MAPTCYP3A4MAPK1HTTTP53
SCHEMBL3050000 0.74 SIRT6 (0.43) MAPTCYP3A4MAPK1HTTTP53
SCHEMBL3060338 0.74 MAPT (0.60) MAPTCYP3A4HTTTP53LMNA
SCHEMBL5692196 0.71 PTGES (0.38) ALDH1A1ARPGR
SCHEMBL5692155 0.70 MAPT (0.46) MAPTHTTLMNAALDH1A1CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1654221-A2 ANILINE DERIVATIVED ANDROGEN-, GLUCOCORTICOID-, MINERALCORTICOID- AND PROGESTERONE- RECEPTOR MODULATORS SMITHKLINE BEECHAM CORPORATION (US) 2006-05-10 EP claimed
WO-2005000795-A2 ANILINE DERIVATIVED ANDROGEN-, GLUCOCORTICOID-, MINERALCORTICOID- AND PROGESTERONE- RECEPTOR MODULATORS SMITHKLINE BEECHAM CORPORATION (US) 2005-01-06 WO claimed